Subjective experience and striatal dopamine D2 receptor occupancy in patients with schizophrenia stabilized by olanzapine or risperidone
Subjective experience and striatal dopamine D2 receptor occupancy in patients with schizophrenia stabilized by olanzapine or risperidone
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DOI：
10.1176/appi.ajp.157.6.1019
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发表时间：
2000-06-01
影响因子：
17.7
通讯作者：
Booij, J
中科院分区：
文献类型：
--
作者：
de Haan, L;Lavalaye, J;Booij, J
目的：作者的目的是研究稳定的精神分裂症患者在奥氮平或利培酮治疗期间的主观体验与多巴胺D-2受体占用率之间的关系。评估主观经验、精神病理学和锥体外系症状，并使用[（123）]碘苯甲酰胺单光子发射计算机断层扫描确定D2受体占用率，结果：多巴胺D-2受体占用率与精神分裂症患者的主观经历、抑郁和阴性症状有关，但与锥体外系症状无关。这些结果提供了初步的证据，负性主观经验与高D-2受体占用。需要进行纵向研究，因为这种关系可能对给药策略有影响。
Objective: The authors' goal was to study the relationship between subjective experience during treatment with olanzapine or risperidone and dopamine D-2 receptor occupancy in stabilized patients with schizophrenia.Method: Subjective experience, psychopathology, and extrapyramidal symptoms were assessed, and D2 receptor occupancy was determined with [(123)]iodobenzamide single photon emission computed tomography, in 22 patients whose schizophrenia was stabilized by olanzapine or risperidone.Results: Subjective experience, depression, and negative symptoms were related to dopamine D-2 receptor occupancy, but extrapyramidal symptoms were not.Conclusions: These results provide preliminary evidence that negative subjective experience is related to high D-2 receptor occupancy. Longitudinal study is required because this relationship may have implications for dosing strategies.