Biological properties of extracellular vesicles and their physiological functions.
Biological properties of extracellular vesicles and their physiological functions.
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DOI：
10.3402/jev.v4.27066
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发表时间：
2015
影响因子：
16
通讯作者：
De Wever O
中科院分区：
文献类型：
--
作者：
Yáñez-Mó M;Siljander PR;Andreu Z;Zavec AB;Borràs FE;Buzas EI;Buzas K;Casal E;Cappello F;Carvalho J;Colás E;Cordeiro-da Silva A;Fais S;Falcon-Perez JM;Ghobrial IM;Giebel B;Gimona M;Graner M;Gursel I;Gursel M;Heegaard NH;Hendrix A;Kierulf P;Kokubun K;Kosanovic M;Kralj-Iglic V;Krämer-Albers EM;Laitinen S;Lässer C;Lener T;Ligeti E;Linē A;Lipps G;Llorente A;Lötvall J;Manček-Keber M;Marcilla A;Mittelbrunn M;Nazarenko I;Nolte-'t Hoen EN;Nyman TA;O'Driscoll L;Olivan M;Oliveira C;Pállinger É;Del Portillo HA;Reventós J;Rigau M;Rohde E;Sammar M;Sánchez-Madrid F;Santarém N;Schallmoser K;Ostenfeld MS;Stoorvogel W;Stukelj R;Van der Grein SG;Vasconcelos MH;Wauben MH;De Wever O
在过去的十年中，细胞外囊泡（EV）已被认为是细胞间通讯的有效载体，无论是在原核生物和真核生物。这是由于它们能够转移蛋白质、脂质和核酸，从而影响受体和亲本细胞的各种生理和病理功能。虽然深入的研究已经针对EV在不同病理过程中的作用，例如，在癌症和自身免疫性疾病中，EV介导的稳态维持和生理功能的调节仍然较少探索。在这里，我们全面概述了目前对电动汽车生理作用的理解，这是由众包撰写的，借鉴了27个欧洲国家，美国和澳大利亚的科学家，临床医生和行业的独特电动汽车专业知识。这篇评论的目的是相关的研究人员已经在EV生物学和新人谁会遇到这个通用的细胞生物系统。因此，在这里，我们解决了从细胞系统到器官的各种组织和体液中EV的分子含量和功能。我们还回顾了EV在细菌，低等真核生物和植物中的生理机制，以突出这一新兴通信系统的功能一致性。
In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity to transfer proteins, lipids and nucleic acids, thereby influencing various physiological and pathological functions of both recipient and parent cells. While intensive investigation has targeted the role of EVs in different pathological processes, for example, in cancer and autoimmune diseases, the EV-mediated maintenance of homeostasis and the regulation of physiological functions have remained less explored. Here, we provide a comprehensive overview of the current understanding of the physiological roles of EVs, which has been written by crowd-sourcing, drawing on the unique EV expertise of academia-based scientists, clinicians and industry based in 27 European countries, the United States and Australia. This review is intended to be of relevance to both researchers already working on EV biology and to newcomers who will encounter this universal cell biological system. Therefore, here we address the molecular contents and functions of EVs in various tissues and body fluids from cell systems to organs. We also review the physiological mechanisms of EVs in bacteria, lower eukaryotes and plants to highlight the functional uniformity of this emerging communication system.