New imidazole alkaloids and zinc complexes from the Micronesian sponge Leucetta cf. chagosensis
New imidazole alkaloids and zinc complexes from the Micronesian sponge Leucetta cf. chagosensis
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DOI：
10.1021/np970453q
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发表时间：
1998-03-01
影响因子：
5.1
通讯作者：
Kelly-Borges, M
中科院分区：
文献类型：
--
作者：
Fu, X;Schmitz, FJ;Kelly-Borges, M
从太平洋海绵Leucetta cf.中分离得到4个新的咪唑类生物碱2-5，沿着已知的异脒B（1）。chagosensis，采自密克罗尼西亚联邦的雅普。其中，4和5是衍生自异钠脒B和异钠脒D的锌络合物。新化合物的结构由光谱数据确定。异脒D（3）对黑曲霉菌有较弱的抑菌活性，MIC为100 μ g/mL。
Four new imidazole alkaloids, 2-5, along with the known isonaamidine B (1) were isolated from a Pacific sponge, Leucetta cf. chagosensis, collected from Yap, Federated States of Micronesia. Among these, 4 and 5 are zinc complexes derived from isonaamidine B and isonaamidine D. The structures of the new compounds were elucidated from spectral data. Isonaamidine D (3) showed weakly antifungal activity against Aspergillus niger with MIC = 100 mu g/mL.