The molecular biology of rabies viruses.
The molecular biology of rabies viruses.
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DOI：
10.1093/clinids/10.supplement_4.s771
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发表时间：
1988-11
期刊：
影响因子：
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通讯作者：
W. Wunner;Jovi K. Larson;Bernhard Dietzschold;Carolyn L. Smith
中科院分区：
文献类型：
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作者：
W. Wunner;Jovi K. Larson;Bernhard Dietzschold;Carolyn L. Smith
对几种固定的狂犬病毒毒株的RNA和蛋白质进行比较核苷酸和推断氨基酸序列分析，可以详细表征单个病毒成分的结构-功能关系。从狂犬病毒5个基因中的4个基因的完整核苷酸序列和基因组的4个基因间区推断出狂犬病毒的几个独特特征。分析最广泛的狂犬病毒基因是表面糖蛋白基因。直接比较推断出的糖蛋白变体的氨基酸序列，可以确定糖蛋白上结合病毒中和抗体的特定位点，并鉴定出与病毒致病性相关的表位。对糖蛋白免疫原性活性的结构要求也进行了研究。本文介绍了狂犬病毒分子生物学的概况，并介绍了不同狂犬病毒成分的免疫生物学特性的知识现状。
Comparative nucleotide and deduced amino acid sequence analyses of the RNA and proteins of several fixed rabies virus strains have allowed detailed characterization of structural-functional relations of individual virus components. Several unique features of rabies viruses have been deduced from the complete nucleotide sequences of four of the five genes and the four intergenic regions of the genome. The most extensively analyzed rabies virus gene has been that of the surface glycoprotein. Direct comparisons between the deduced amino acid sequences of glycoprotein variants have led to the location of specific sites on the glycoprotein that bind virus-neutralizing antibodies and to the identification of an epitope correlating with viral pathogenicity. Structural requirements for immunogenic activity within the glycoprotein have also been investigated. This article presents an overview of the molecular biology of rabies viruses and describes the current state of knowledge of immunobiologic characteristics of different rabies virus components.