Cholesterol synthesis is increased and absorption decreased in non-alcoholic fatty liver disease independent of obesity
Cholesterol synthesis is increased and absorption decreased in non-alcoholic fatty liver disease independent of obesity
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DOI：
10.1016/j.jhep.2010.05.037
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发表时间：
2011-01-01
影响因子：
25.7
通讯作者：
Yki-Jarvinen, Hannele
中科院分区：
文献类型：
--
作者：
Simonen, Piia;Kotronen, Anna;Yki-Jarvinen, Hannele
背景与目的：非酒精性脂肪性肝病（NAFLD）与葡萄糖和脂蛋白代谢受损有关。然而，NAFLD中胆固醇的代谢仍未被研究。我们研究了242名非糖尿病患者脂肪肝对胆固醇代谢的影响。方法：采用质子磁共振波谱法测定肝脏脂肪含量。用血清非胆固醇固醇（胆固醇合成和吸收的替代标志物）测定胆固醇代谢。采用气液色谱法进行分析。结果：NAFLD 114例，肝脏脂肪含量正常128例。与体重指数无关，NAFLD患者反映胆固醇合成的非胆固醇固醇（胆固醇、去甾醇和胆甾醇）高于对照组，反映胆固醇吸收的非胆固醇固醇（胆固醇和植物固醇）低于对照组。肝脏脂肪含量与胆固醇合成标志物正相关（r = 0.262 ~ 0.344, p < 0.001），与胆固醇吸收标志物负相关（r = -0.299 ~ -0.336, p < 0.001）
Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is associated with impaired glucose and lipoprotein metabolism. However, the metabolism of cholesterol in NAFLD remains unexplored. We investigated how fatty liver influences cholesterol metabolism in 242 non-diabetic subjects.Methods: Liver fat content was measured with proton magnetic resonance spectroscopy. Cholesterol metabolism was assayed with serum non-cholesterol sterols, surrogate markers of cholesterol synthesis and absorption. The analyses were performed with gas-liquid chromatography.Results: A total of 114 subjects had NAFLD and 128 subjects had normal liver fat content. Non-cholesterol sterols reflecting cholesterol synthesis (cholestenol, desmosterol, and lathosterol) were higher, and those reflecting cholesterol absorption (cholestanol and plant sterols) were lower in subjects with NAFLD than in controls, independent of body mass index. Liver fat content was positively associated with markers of cholesterol synthesis (r = from 0.262 to 0.344, p < 0.001 for all) and inversely associated with markers of cholesterol absorption (r = from -0.299 to -0.336, p