Relationship of serum advanced glycation end products with deterioration of periodontitis in type 2 diabetes patients
Relationship of serum advanced glycation end products with deterioration of periodontitis in type 2 diabetes patients
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DOI：
10.1902/jop.2006.77.1.15
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发表时间：
2006-01-01
影响因子：
4.3
通讯作者：
Amano, Atsuo
中科院分区：
文献类型：
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作者：
Takeda, Munehiro;Ojima, Miki;Amano, Atsuo
背景：已证明糖尿病与慢性牙周炎之间存在密切关系。我们之前发现，带有II型fimA基因的牙龈卟啉单胞菌是一种与糖尿病牙周炎患者病情恶化密切相关的感染因子。在本研究中，我们检查了其他生物标志物是否与2型糖尿病个体中常见的牙周炎的发生和恶化有关。方法：共招募了97名患有和不患有牙周炎的2型糖尿病患者，并对他们的牙周和糖尿病状况进行了分析。将每位受试者所有牙齿中附着损失> 5 mm的牙齿的比例（%）用作牙周恶化的指标。检测外周血中糖化血红蛋白 (HbA1c)、晚期糖基化终末产物 (AGES)、C 反应蛋白 (CRP) 和细胞因子（肿瘤坏死因子 [TNF]-α 和白细胞介素 [IL]-1 β）的水平。还检查了龈下菌斑样本中是否存在伴放线放线杆菌、福赛坦纳氏菌、齿状密螺旋体和结果：血清AGES与牙周炎的恶化显着相关，而其他血清生化标志物或细菌的出现与牙周炎的恶化没有显示出明显的关系。结论：AGES可能是与糖尿病性牙周炎相关的因素，并且可能作为反映牙周炎恶化的生物标志物。
Background: A close relationship between diabetes and chronic periodontitis has been demonstrated. We previously found that Porphyromonas gingivalis with the type II fimA gene is an infectious factor closely associated with the deterioration seen in diabetic periodontitis patients. In the present study, we examined whether other biomarkers are related to the development and deterioration of periodontitis often seen in type 2 diabetic individuals.Methods: A total of 97 type 2 diabetes patients with and without periodontitis were recruited, and their periodontal and diabetic conditions were analyzed. The ratio (%) of teeth with an attachment loss > 5 mm among all teeth in each subject was used as an index of periodontal deterioration. Peripheral blood was tested for levels of glycated hemoglobin (HbA1c), advanced glycation end products (AGES), C-reactive protein (CRP), and cytokines (tumor necrosis factor [TNF]-alpha and interleukin [IL]-1 beta. Subgingival plaque samples were also examined for the occurrences of Actinobacillus actinomycetemcomitans, Tannerella forsythensis, Treponema denticola, and Prevotella intermedia.Results: Serum AGES were significantly associated with deterioration of periodontitis, whereas no other serum biochemical marker or bacterial occurrence showed a clear relationship with that condition.Conclusion: AGES may be factors associated with diabetic periodontitis and may be useful as biomarkers that reflect such deterioration.