Prevalence of dementia in an urban Indian population
Prevalence of dementia in an urban Indian population
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DOI：
10.1017/s1041610201007852
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发表时间：
2001-12-01
影响因子：
7
通讯作者：
Sachdeva, S
中科院分区：
文献类型：
--
作者：
Vas, CJ;Pinto, C;Sachdeva, S
本文报道了印度孟买城市社区居民中痴呆症的3年流行病学调查结果，其中确定了所有类型痴呆症的患病率。方法：本研究分三个阶段进行。第一阶段：在30，000名年龄在40岁或以上的受试者中，24，488人（男性= 11，875;女性= 12，613）完成了基于Sandoz临床评估老年量表的自我报告或访谈者评分方案，但5，512人（18.37%）拒绝参与。方案评分的可能范围为0 - 34。第二阶段：在此阶段选择得分高于平均值+2 SD的人，其中使用简易精神状态检查的修改和翻译版本筛选这些人的认知功能。评分低于第5百分位数的个体被纳入第3阶段，并接受详细的神经学、精神病学和神经心理学评价以及血液学、放射学、心电图和脑电图检查。诊断由神经科医生、精神科医生和心理学家使用DSM-IV诊断标准联合进行。受试者还进行了临床痴呆评定（CDR）量表评分，并评估了日常生活活动。结果：在这24，488人的人群中确定了105名痴呆患者（CDR大于或等于0.5）。40岁及以上老年痴呆症患病率为0.43%，65岁及以上老年痴呆症患病率为2.44%。78名患者的CDR大于或等于1，总患病率为0.32%，65岁及以上患者的患病率为1.81%。老年痴呆症（AD）在人群中的总患病率为0.25%，65岁及以上人群的患病率为1.5%。AD（n = 62; 65%）是痴呆的最常见原因，其次是血管性痴呆（n = 23; 22%）。AD组中女性（n = 38）多于男性（n = 24）。随着年龄的增长，痴呆综合征的患病率普遍升高，特别是AD。结论：在接受调查的人群中，AD和其他痴呆症的患病率低于发达国家报告的患病率，但与印度其他研究的结果相似。痴呆综合征的患病率随着年龄的增长而增加，与性别无关。AD是最常见的痴呆，女性患病率高于男性。结果进行了讨论方面的预期寿命较短，受影响的人搬迁，以及与发达国家相比，在风险因素的差异。
This article reports the findings of a 3-year epidemiological survey for dementia in an urban community-resident population in Mumbai (Bombay), India, wherein the prevalence of all types of dementia was determined. Method: The study was conducted in three stages. Stage 1: From a potential pool of 30,000 subjects aged 40 years or more, 24,488 (male = 11,875; female = 12,613) persons completed self-report or interviewer-rated protocols based on the Sandoz Clinical Assessment Geriatric Scale, but 5,512 (18.37%) persons refused to participate. Scores on the protocol had a possible range from 0 through 34. Stage 2: Persons with a score +2 SD above the mean were selected in this stage where the persons were screened for cognitive functioning using a modified and translated version of the Mini-Mental State Examination. Individuals who scored below the 5th percentile were included in Stage 3 and underwent a detailed neurological, psychiatric, and neuropsychological evaluation as well as hematological, radiological, electrocardiographic, and electroencephalographic investigations. Diagnoses were made jointly by a neurologist, psychiatrist, and psychologist using the DSM-IV diagnostic criteria. Subjects were also rated on the Clinical Dementia Rating (CDR) scale and assessed for activities of daily living. Results: One hundred five subjects with dementia (CDR greater than or equal to 0.5) were identified in this population of 24,488 persons. The prevalence rate for dementia in those aged 40 years and more was 0.43% and for persons aged 65 and above was 2.44%. Seventy-eight individuals had a CDR of greater than or equal to 1 yielding an overall prevalence rate of 0.32%, and a prevalence rate of 1.81% for those aged 65 years and older. The overall prevalence rate for Alzheimer's disease (AD) in the population was 0.25%, and 1.5% for those aged 65 years and above. AD (n = 62; 65%) was the most common cause of dementia followed by vascular dementia (n = 23; 22%). There were more women (n = 38) than men (n = 24) in the AD group. Increasing age was associated with a higher prevalence of the dementia syndrome in general as well as AD specifically. Conclusion: In the population surveyed, the prevalence of AD and other dementias is less than that reported from developed countries but similar to results of other studies in India. Prevalence of the dementia syndrome increased with age and was not related to gender. AD was the most common dementia and the prevalence was higher in women than in men. Results are discussed with respect to shorter life expectancy, relocation of affected persons, and differences in the risk factors as compared to developed countries.