Clinical Corneal Optical Coherence Elastography Measurement Precision: Effect of Heartbeat and Respiration
Clinical Corneal Optical Coherence Elastography Measurement Precision: Effect of Heartbeat and Respiration
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DOI：
10.1167/tvst.9.5.3
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发表时间：
2020-04-01
影响因子：
3
通讯作者：
Twa, Michael D.
中科院分区：
文献类型：
--
作者：
Lan, Gongpu;Gu, Boyu;Twa, Michael D.
目的：在使用光学相干弹性成像(OCE)对人类角膜生物力学特性进行临床测量时，正常的生理运动(如呼吸和心跳)会引起眼球运动。我们量化了呼吸和心脏诱发的眼球运动对临床角膜OCE测量精度和重复性的影响。方法：使用低力、微空气脉冲组织刺激和高分辨率相敏光学相干断层扫描(OCT)成像进行角膜OCE测量。在70 kHz的采样率和三种不同的刺激压力(20-60Pa.)下，测量角膜顶端的轴向表面位移(M型)。结果：呼吸和心脏诱发眼球运动的频率(0.1~1 Hz)明显低于空气脉冲诱发的角膜组织变形(接近250 Hz)，而眼球运动的幅度(最大可达+/-50微米)明显大于空气脉冲诱发的角膜组织变形(接近250 Hz)。
Purpose: Normal physiological movements (e.g., respiration and heartbeat) induce eye motions during clinical measurements of human corneal biomechanical properties using optical coherence elastography (OCE). We quantified the effects of respiratory and cardiac-induced eye motions on clinical corneal OCE measurement precision and repeatability.Methods: Corneal OCE was performed using low-force, micro-air-pulse tissue stimulation and high-resolution phase-sensitive optical coherence tomography (OCT) imaging. Axial surface displacements of the corneal apex were measured (M-mode) at a 70-kHz sampling rate and three different stimulation pressures (20-60 Pa). Simultaneously, the axial corneal position was tracked with structural OCT imaging, while the heartrate and respiration were monitored over a 90 second period.Results: Respiratory- and cardiac-induced eye motions have distinctly lower frequency (0.1-1 Hz) and much greater amplitude (up to +/- 50 mu m movements) than air-pulse-induced corneal tissue deformations (similar to 250 Hz,