The circadian epigenome: how metabolism talks to chromatin remodeling.
The circadian epigenome: how metabolism talks to chromatin remodeling.
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DOI：
10.1016/j.ceb.2013.01.003
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发表时间：
2013-04
影响因子：
7.5
通讯作者：
Sassone-Corsi P
中科院分区：
文献类型：
--
作者：
Aguilar-Arnal L;Sassone-Corsi P
昼夜节律存在于大多数生物体中，并具有24小时的周期性，支配着许多生理和代谢功能。在过去的几年里，一项重要的研究工作发现了在昼夜节律和新陈代谢途径之间交叉的新线索。在分子水平上，时钟机械负责建立一个昼夜节律的表观基因组，这可以受到代谢信号的调节。事实上，当昼夜节律受损时，代谢疾病的发展就会明显地受到昼夜节律的控制。因此，对昼夜节律的药物调节有望为治疗新陈代谢和睡眠障碍提供新的途径。
Circadian rhythms occur in most of the living organisms, and with a 24 hour periodicity govern a number of physiological and metabolic functions. During the past few years, an important research effort has uncovered new trails that intersect between circadian rhythms and metabolic pathways. At a molecular level, the clock machinery is responsible for the establishment of a circadian epigenome, and this can be modulated by metabolic cues. Indeed, metabolic control by the circadian clock is manifest in the development of metabolic diseases when circadian rhythms are impaired. Thus, pharmacological modulation of circadian rhythms promises new avenues for the treatment of metabolic and sleep disorders.