Alterations of the default mode network and cognitive impairments in patients with chronic obstructive pulmonary disease.
Alterations of the default mode network and cognitive impairments in patients with chronic obstructive pulmonary disease.
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慢性阻塞性肺疾病患者默认模式网络的改变和认知障碍
DOI：
10.2147/copd.s146870
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发表时间：
2018
影响因子：
2.8
通讯作者：
Yu Y
中科院分区：
文献类型：
--
作者：
Hu X;Wang H;Tu Y;Fei M;Yin M;Fei G;Yu Y
背景与目的认知障碍是COPD患者常见的肺外合并症。默认模式网络（DMN）在维持人体正常活动中起着至关重要的作用，其功能可以通过静息状态功能磁共振成像来评估。本研究旨在探讨COPD患者认知与DMN功能变化的相关性。方法纳入130名符合条件的受试者，包括30名对照受试者和83名符合人口统计学特征的COPD患者。所有参与者都进行了认知功能测试，并进行了静息状态功能磁共振成像。结果COPD患者认知功能总分与对照组比较差异有统计学意义（P<0.05），且随气流阻塞程度加重而加重。慢性阻塞性肺病患者DMN中激活的脑区少于正常对照。研究发现，在被试中，DMN的6个激活脑区具有显著不同的功能连接值。同时，左侧后扣带皮层和左侧海马的FC值与认知功能和肺功能有良好的相关性。结论慢性阻塞性肺病患者认知功能障碍与病情严重程度密切相关。DMN激活脑区FC变化可预测认知功能障碍，左侧后扣带皮层和左侧海马可能是COPD患者认知功能障碍相关的重要脑区。
Background and objectives Cognitive impairment is a common extrapulmonary comorbidity in COPD patients. The default mode network (DMN) plays a critical role in maintaining the normal activities of humans, and its function can be evaluated by resting state functional magnetic resonance imaging. The aim of this study was to investigate the correlations between cognition and function changes of the DMN in COPD patients. Methods One hundred and thirteen eligible participants including 30 control subjects and 83 COPD patients matched for demographic characteristics were recruited. All participants performed cognitive function tests and underwent resting state functional magnetic resonance imaging. Results The total cognitive function scores of COPD patients were significantly different from those of control subjects (P<0.05) and worsened with the degree of airflow obstruction. The activated brain regions in the DMN of COPD patients were less than those of normal controls. Six activated brain regions in the DMN were found to develop significantly different functional connectivity (FC) values among the subjects. Meanwhile, the FC values of the left posterior cingulate cortex and left hippocampus correlated well with cognitive functions and pulmonary function. Conclusion COPD patients have cognitive impairments that correlate well with disease severity. FC changes in activated brain regions in the DMN may predict cognitive impairment, and the left posterior cingulate cortex and left hippocampus may be important brain regions related to cognitive impairment in COPD patients.