Antibody Responses to Periodontopathic Bacteria in Relation to Rheumatoid Arthritis in Japanese Adults
Antibody Responses to Periodontopathic Bacteria in Relation to Rheumatoid Arthritis in Japanese Adults
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DOI：
10.1902/jop.2011.110020
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发表时间：
2011-10-01
影响因子：
4.3
通讯作者：
Yoshie, Hiromasa
中科院分区：
文献类型：
--
作者：
Okada, Moe;Kobayashi, Tetsuo;Yoshie, Hiromasa
背景：牙周病细菌被认为是类风湿性关节炎（RA）的病因之一。抗环瓜氨酸肽（CCP）抗体和类风湿因子（RF）与RA相关。本研究探讨是否牙周致病菌的抗体血清水平可能会影响RA的临床和实验室资料。方法：研究参与者包括80例RA患者，和38个年龄，性别，吸烟状况，牙周状况平衡的健康对照。牙周及牙周炎检查后，检测血清牙龈卟啉单胞菌（Pg）、中间普氏菌（Prevotella intermedia）、伴放线杆菌（Aggregatibacter actinomycetemcomitans）用酶联免疫吸附试验测定了伴放线放线杆菌（Actinobacillusactinomycetemcomitans）、腐蚀艾肯氏菌（Eikenellacromodens，Ec）和抗CCP抗体及RF。RA患者抗Pg和抗CCP抗体水平显著高于对照组（P = 0.04和P < 0.0001）。RA患者IgG对Aa和Ec的反应明显低于对照组（P < 0.0001和P = 0.0001）。多因素Logistic回归分析显示，在调整年龄、性别和吸烟后，抗Pg和抗Aa IgG应答与RA显著相关（P = 0.005和P = 0.02）。结论：RA患者血清中抗Pg IgG抗体水平与RA的发生有关，并可能影响RA患者的血清RF水平和牙周状况。牙周病学杂志2011; 82：1433-1441。
Background: Periodontopathic bacteria have been implicated as contributory to the etiology of rheumatoid arthritis (RA). Anticyclic citrullinated peptide (CCP) antibodies and rheumatoid factor (RF) were shown to be associated with RA. This study examines whether serum levels of antibodies to periodontopathic bacteria may affect clinical and laboratory profiles of RA.Methods: The study participants consisted of 80 patients with RA, and 38 age-, sex-, smoking status-, and periodontal condition-balanced healthy controls. After periodontal and rheumatologic examination, serum levels of immunoglobulin G(IgG) antibodies to Porphyromonas gingivalis (Pg), Prevotella intermedia, Aggregatibacter actinomycetemcomitans (Aa) (previously Actinobacillus actinomycetemcomitans), and Eikenella corrodens (Ec) and those of anti-CCP antibodies and RF were determined by an enzyme-linked immunosorbent assay.Results: Patients with RA showed significantly higher levels of anti-Pg and anti-CCP antibodies than controls (P = 0.04 and P < 0.0001). In contrast, IgG responses to Aa and Ec in patients with RA were significantly lower than those in controls (P < 0.0001 and P = 0.0001). Multiple logistic regression analysis revealed a significant association of anti-Pg and anti-Aa IgG responses with RA, after adjustment for age, sex, and smoking (P = 0.005 and P = 0.02). Anti-Pg titer displayed a significant correlation with RF levels, probing depth, and clinical attachment level (P = 0.03, P = 0.03, and P = 0.02).Conclusion: These results suggest that serum levels of anti-Pg IgG antibodies were associated with RA, and might affect serum levels of RF and periodontal condition in patients with RA. J Periodontol 2011; 82: 1433-1441.