Hepcidin in the diagnosis of iron disorders
Hepcidin in the diagnosis of iron disorders
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DOI：
10.1182/blood-2015-12-639112
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发表时间：
2016-06-09
期刊：
影响因子：
20.3
通讯作者：
Swinkels, Dorine W.
中科院分区：
文献类型：
--
作者：
Girelli, Domenico;Nemeth, Elizabeta;Swinkels, Dorine W.
2001年铁调节激素hepcidin的发现彻底改变了我们对铁紊乱的理解，其测量将促进这些疾病的诊断/治疗。虽然已经开发了几种检测方法，但仍然缺乏金标准，并且正在努力实现统一。尽管如此，已经可以看到有希望的应用，从使用hepcidin水平诊断铁难治性缺铁性贫血到全球卫生应用，例如指导感染负担高的发展中国家的安全补铁。
The discovery of the iron-regulatory hormone hepcidin in 2001 has revolutionized our understanding of iron disorders, and its measurement should advance diagnosis/treatment of these conditions. Although several assays have been developed, a gold standard is still lacking, and efforts toward harmonization are ongoing. Nevertheless, promising applications can already be glimpsed, ranging from the use of hepcidin levels for diagnosing iron-refractory iron deficiency anemia to global health applications such as guiding safe iron supplementation in developing countries with high infection burden.