Reemergence of adenovirus type 4 acute respiratory disease in military trainees: Report of an outbreak during a lapse in vaccination
Reemergence of adenovirus type 4 acute respiratory disease in military trainees: Report of an outbreak during a lapse in vaccination
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DOI：
10.1086/314772
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发表时间：
1999-06-01
影响因子：
6.4
通讯作者：
Brundage, JF
中科院分区：
文献类型：
--
作者：
Barraza, EM;Ludwig, SL;Brundage, JF
1995年4月23日至5月13日，在南卡罗来纳州的杰克逊堡进行基本训练的士兵中爆发了急性呼吸道疾病住院。受影响最严重的军事单位的每周住院率达到11.6%。从患者样本中进行的病毒分离和血清学研究确定该病原体为腺病毒4型。在1971年开始接种针对腺病毒4型和7型的疫苗之前，这些血清型是基础学员中ARD的主要原因。在使用疫苗时没有报告暴发。由于后勤方面的失误，疫苗生产暂时中断，从1994年夏天到1995年3月下旬，新到的受训人员没有接种腺病毒疫苗。唯一的制造商已经永久停止了腺病毒疫苗的生产。所有4型疫苗供应现已耗尽。这次爆发表明新兵对腺病毒4型的持续易感性，并警告未来的爆发。
From 23 April to 13 May 1995, an outbreak of acute respiratory disease (ARD) hospitalizations occurred in basic training soldiers at Fort Jackson, South Carolina. Weekly hospitalization rates for the most affected military unit reached 11.6%. Virus isolation and serologic studies from a sample of patients identified the agent as adenovirus type 4. Prior to starting vaccinations against adenovirus types 4 and 7 in 1971, these serotypes were the major causes of ARD in basic trainees. No outbreaks were reported when the vaccines were used. A logistical error temporarily interrupted vaccine production, and newly arriving trainees received no adenovirus vaccines from the summer of 1994 through late March 1995, This outbreak occurred in unvaccinated soldiers. The sole manufacturer has permanently stopped adenovirus vaccine production. All type 4 vaccine supplies are now depleted. This outbreak demonstrates continued susceptibility of military recruits to adenovirus type 4 and warns of future outbreaks.