The-116C/G Polymorphism in XBP1 Gene is Associated with Psychiatric Illness in Asian Population: A Meta-Analysis
The-116C/G Polymorphism in XBP1 Gene is Associated with Psychiatric Illness in Asian Population: A Meta-Analysis
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DOI：
10.1002/ajmg.b.32271
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发表时间：
2014-12-01
影响因子：
2.8
通讯作者：
Xue, Zheng
中科院分区：
文献类型：
--
作者：
Cheng, Dan;Zhang, Kan;Xue, Zheng
X-box结合蛋白1（X-box binding protein 1，XBP 1）是一种重要的转录因子，在精神疾病的发病机制中起重要作用。XBP 1 - 116 C/G多态性与精神疾病风险之间的关联已在不同人群中进行了研究。然而，这些研究的结果仍然相互矛盾。因此，我们进行了系统的荟萃分析，以评估之间的关联性XBP 1-116 C/G多态性和整体精神疾病的风险。检索Pubmed、Embase和中国生物医学文献数据库（CBM）中截至2014年7月31日发表的关于XBP 1 - 116 C/G多态性与精神疾病风险相关性的病例对照研究。比值比（OR）和95%置信区间（CI）用于评估这种关联的强度。纳入了14项病例对照研究，包括3，512例病例和4，889例对照。总体而言，未发现XBP 1 - 116 C/G多态性与精神疾病的风险有显著相关性（C/G vs. C/C：OR=1.04，95%CI=0.92-1.17，P=0.54）。然而，在亚洲人群中，该多态性与精神疾病有显著相关性（C/G vs. C/C：OR=1.27，95%CI=1.00-1.61，P=0.05; G/G+C/G vs. C/C：OR=1.32，95%CI=1.05-1.65，P=0.02）。此外，我们发现，在亚洲人群中，XBP 1 - 116 C/G多态性与双相情感障碍的风险显著相关（C/G vs. C/C：OR=1.81，95%CI=1.15-2.86，P=0.01）。XBP 1 - 116 C/G多态性与亚洲人群双相情感障碍风险增加相关(c)2014 Wiley Periodicals，Inc.
X-box binding protein 1 (XBP1) is a pivotal transcription factor and plays an important role in the pathogenesis of psychiatric illness. The association between XBP1 -116C/G polymorphism and risk of psychiatric illness has been investigated in different populations. However, the results of these studies remain conflicting. Therefore, we performed a systematic meta-analysis to evaluate the association between XBP1 -116C/G polymorphism and the overall psychiatric illness risk. Pubmed, Embase, and Chinese Biomedical Literature Database (CBM) were searched for case-control studies on the association between XBP1 -116C/G polymorphism and psychiatric illness risk published up to July 31, 2014. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to access the strength of this association. Fourteen case-control studies including 3,512 cases and 4,889 controls were included. Overall, no significant association was found between XBP1 -116C/G polymorphism and the risk of psychiatric illness (C/G vs. C/C: OR=1.04, 95%CI=0.92-1.17, P=0.54). However, there was a significant association between this polymorphism and the psychiatric illness in Asian population (C/G vs. C/C: OR=1.27, 95%CI=1.00-1.61, P=0.05; G/G+C/G vs. C/C: OR=1.32, 95%CI=1.05-1.65, P=0.02). Furthermore, we found a significant association between XBP1 -116C/G polymorphism and the risk of bipolar disorder in Asian population (C/G vs. C/C: OR=1.81, 95%CI=1.15-2.86, P=0.01). The XBP1 -116C/G polymorphism is associated with an increased risk of bipolar disorder in Asian population. (c) 2014 Wiley Periodicals, Inc.