Early medical and behavioral characteristics of NICU infants later classified with ASD.
Early medical and behavioral characteristics of NICU infants later classified with ASD.
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DOI：
10.1542/peds.2009-2680
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发表时间：
2010-09
期刊：
影响因子：
8
通讯作者：
Harin A
中科院分区：
文献类型：
--
作者：
Karmel BZ;Gardner JM;Meade LS;Cohen IL;London E;Flory MJ;Lennon EM;Miroshnichenko I;Rabinowitz S;Parab S;Barone A;Harin A
最近的证据表明，自闭症谱系障碍（ASD）在新生儿重症监护室毕业生的患病率较高。这项研究的目的是回顾性地确定在NICU婴儿中更常见的早期行为，这些婴儿继续发展ASD。28名后来被诊断为ASD的NICU毕业生与1994年至2005年招募的2169名其他NICU毕业生进行了比较。他们在性别、胎龄和出生队列方面存在差异。这些特征被用来抽取一个匹配的对照样本（n = 112），以确定哪些早期行为（如果有的话）可以区分随后的ASD诊断。在目标年龄（调整妊娠）的行为测试包括快速新生儿神经行为评估（出院，1个月），Aroxin调节的注意力（出院，1和4个月），和贝利婴儿发育量表（多次，4-25个月）。在1个月时，ASD儿童（而非对照组儿童）具有持续的神经行为异常和更高的不对称视觉跟踪和手臂张力缺陷发生率。在4个月时，ASD儿童比对照组儿童继续对更高数量的刺激有视觉偏好，表现得更像新生儿。与对照组儿童不同，ASD儿童在7至10个月内的精神和运动表现下降，类似于严重中枢神经系统受累的婴儿。NICU毕业生后来接受ASD诊断和匹配的NICU对照儿童之间特定行为领域的差异可能在婴儿早期被识别。该队列的研究可以提供见解，以帮助理解和检测早期残疾，包括ASD。
Recent evidence suggests higher prevalence of autism spectrum disorder (ASD) in NICU graduates. This aim of this study was to identify retrospectively early behaviors found more frequently in NICU infants who went on to develop ASD. Twenty-eight NICU graduates who later received a diagnosis of ASD were compared with 2169 other NICU graduates recruited from 1994 to 2005. They differed in gender, gestational age, and birth cohort. These characteristics were used to draw a matched control sample (n = 112) to determine which, if any, early behaviors discriminated subsequent ASD diagnosis. Behavioral testing at targeted ages (adjusted for gestation) included the Rapid Neonatal Neurobehavioral Assessment (hospital discharge, 1 month), Arousal-Modulated Attention (hospital discharge, 1 and 4 months), and Bayley Scales of Infant Development (multiple times, 4–25 months). At 1 month, children with ASD but not control children had persistent neurobehavioral abnormalities and higher incidences of asymmetric visual tracking and arm tone deficits. At 4 months, children with ASD had continued visual preference for higher amounts of stimulation than did control children, behaving more like newborns. Unlike control children, children with ASD had declining mental and motor performance by 7 to 10 months, resembling infants with severe central nervous system involvement. Differences in specific behavior domains between NICU graduates who later receive a diagnosis of ASD and matched NICU control children may be identified in early infancy. Studies with this cohort may provide insights to help understand and detect early disabilities, including ASD.
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影响因子：
1.9
作者：
Connors, SL;Crowell, DE;Zimmerman, AW
通讯作者：
Zimmerman, AW
影响因子：
3.9
作者：
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通讯作者：
Gardner, Judith M.
影响因子：
56.9
作者：
FANTZ, RL
通讯作者：
FANTZ, RL
影响因子：
10.6
作者：
Ashwin, Emma;Ashwin, Chris;Baron-Cohen, Simon
通讯作者：
Baron-Cohen, Simon
DOI：
10.1111/j.1469-8749.2007.00734.x
发表时间：
2007-10-01
影响因子：
3.8
作者：
Dziuk, M. A.;Larson, J. C. Gidley;Mostofsky, S. H.
通讯作者：
Mostofsky, S. H.