Cladribine in the treatment of hairy-cell leukaemia
Cladribine in the treatment of hairy-cell leukaemia
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DOI：
10.1016/s1521-6926(02)00089-0
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发表时间：
2003-03-01
影响因子：
2.1
通讯作者：
Saven, A
中科院分区：
文献类型：
--
作者：
Goodman, GR;Beutler, E;Saven, A
克拉立滨是一种嘌呤核苷类似物，对毛细胞白血病患者是一种安全有效的治疗方法。每日0.09毫克/公斤，连续静脉滴注7天。本章讨论了克拉曲滨的历史、基本原理、化学结构和作用机制。对治疗的适应症和临床使用指南进行了综述。综述了毛细胞性白血病对克拉曲林的反应、急性和慢性并发症以及继发恶性肿瘤的风险。这一章最后有一节是关于抢救疗法的。
Cladribine, a purine nucleoside analogue, is a safe and effective treatment for patients with hairy-cell leukaemia. It is administered at a dose of 0.09 mg/kg daily as a continuous intravenous infusion over 7 days. This chapter discusses the history, rationale, chemical structure and mechanism of action of cladribine. The indications for therapy and guidelines for clinical usage are reviewed. The response of hairy-cell leukaemia to cladribine, the acute and chronic complications and the risk for second malignancies are summarized. The chapter concludes with a section on salvage therapy.