Retinal origin of direction selectivity in the superior colliculus.
Retinal origin of direction selectivity in the superior colliculus.
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上丘方向选择性的视网膜起源
DOI：
10.1038/nn.4498
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发表时间：
2017-04
影响因子：
25
通讯作者：
Cang J
中科院分区：
文献类型：
--
作者：
Shi X;Barchini J;Ledesma HA;Koren D;Jin Y;Liu X;Wei W;Cang J
检测环境中的视觉特征，如运动方向，对生存至关重要。引起主要视觉中枢上级丘（SC）方向选择性的电路机制完全未知。我们光遗传学地分离了单个方向选择性SC神经元接收的视网膜输入，并发现由于来自类似调谐的视网膜神经节细胞的精确会聚输入，它们已经具有选择性。方向选择性视网膜输入被耳蜗内回路线性放大，而不改变其优选方向或选择性水平。最后，使用双光子钙成像，我们表明，SC方向的选择性显着降低，在转基因小鼠视网膜的选择性下降。总之，我们的研究表明，在SC的方向选择性的视网膜起源，并揭示了一个中央视觉缺陷的结果，改变功能的选择性视网膜。
Detecting visual features in the environment, such as motion direction, is crucial for survival. The circuit mechanisms that give rise to direction selectivity in a major visual center, the superior colliculus (SC), are entirely unknown. We optogenetically isolate the retinal inputs that individual direction-selective SC neurons receive and find that they are already selective as a result of precisely converging inputs from similarly tuned retinal ganglion cells. The direction-selective retinal input is linearly amplified by intracollicular circuits without changing its preferred direction or level of selectivity. Finally, using two-photon calcium imaging, we show that SC direction selectivity is dramatically reduced in transgenic mice that have decreased retinal selectivity. Together, our studies demonstrate a retinal origin of direction selectivity in the SC and reveal a central visual deficit as a consequence of altered feature selectivity in the retina.