Semantic and affective priming as a function of stimulation of the subthalamic nucleus in Parkinson's disease
Semantic and affective priming as a function of stimulation of the subthalamic nucleus in Parkinson's disease
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DOI：
10.1093/brain/awm059
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发表时间：
2007-05-01
期刊：
影响因子：
14.5
通讯作者：
Silburn, Peter A.
中科院分区：
文献类型：
--
作者：
Castner, Joanna E.;Chenery, Helen J.;Silburn, Peter A.
词汇语义和情感处理缺陷与帕金森病有关。本研究采用情感启动和语义启动相结合的实验范式，考察了词汇语义自动加工和控制加工、情绪评价的自动激活以及表达消极和中性情绪内涵的词汇的加工。18名帕金森氏病患者接受了丘脑底核（DBS）脑深部电刺激手术，在短刺激和长刺激起始期（SOA），在开和关刺激条件下完成了词汇决策任务。19名非神经功能受损的参与者作为对照。结果表明，自动词汇语义和情感评价过程是未受损的帕金森氏病反映在存在可比的语义和情感的启动效应在短SOA在开和关刺激条件下与健康对照组相比。与此相反，帕金森氏病的参与者在关闭刺激条件下表现出一种模式的异常控制词汇语义处理证明了缺乏语义启动效应在长SOA条件。然而，当帕金森病患者接受丘脑刺激时，存在受控的语义启动，这表明丘脑刺激调节了参与这些过程的基底节-丘脑皮质回路。最后，延迟的反应时间为负valenced目标相比，中性valenced目标是明显的参与者与帕金森氏病的刺激条件和控制参与者，但不为帕金森氏病的参与者在关闭刺激条件，这表明偶然评价的负与中性valenced的话在帕金森氏病调制基底神经节丘脑皮层电路。
Lexical-semantic and emotional processing deficits have been associated with Parkinson's disease. This study investigated automatic and controlled lexical-semantic processing, the automatic activation of emotional evaluations, and the processing of words conveying negative and neutral emotional connotations in a combined affective and semantic priming paradigm. Eighteen participants with Parkinson's disease who had undergone surgery for deep brain stimulation (DBS) of the subthalamic nucleus (STN) completed a lexical decision task at short and long stimulus onset asynchronies (SOAs), during on and off stimulation conditions. Nineteen non-neurologically impaired participants acted as controls. The results indicated that automatic lexical-semantic and emotional evaluative processes are unimpaired in Parkinson's disease as reflected in the presence of comparable semantic and affective priming effects at the short SOA in on and off stimulation conditions compared with healthy controls. In contrast, participants with Parkinson's disease in the off stimulation condition showed a pattern of aberrant controlled lexical-semantic processing as evidenced by a lack of semantic priming effects at the long SOA condition. Controlled semantic priming was present, however, when the participants with Parkinson's disease were receiving stimulation of the STN, suggesting that STN stimulation modulates basal ganglia-thalamocortical circuits involved in such processes. Finally, delayed reaction times for negatively valenced targets compared with neutrally valenced targets was evident in participants with Parkinson's disease in the on stimulation condition and control participants, but not for participants with Parkinson's disease in the off stimulation condition, suggesting that the incidental evaluation of negatively versus neutrally valenced words in Parkinson's disease is modulated by basal ganglia-thalamocortical circuits.