RECOMBINANT ALPHA-2 INTERFERON GEL TREATMENT OF RECURRENT HERPES GENITALIS
RECOMBINANT ALPHA-2 INTERFERON GEL TREATMENT OF RECURRENT HERPES GENITALIS
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DOI：
10.1016/0166-3542(92)90044-6
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发表时间：
1992-03-01
影响因子：
7.6
通讯作者：
PLASSE, T
中科院分区：
文献类型：
--
作者：
LEBWOHL, M;SACKS, S;PLASSE, T
在一项随机、双盲、安慰剂对照的临床试验中，对局部应用重组α-2干扰素治疗复发性生殖器疱疹进行了研究。387名患者在八个研究中心接受了干扰素凝胶或安慰剂治疗，连续四天，每天四次。干扰素治疗使病毒脱落的持续时间减少了26%。对于男性患者，结痂时间(17%)以及疼痛和瘙痒的持续时间(34%)也显著减少(21%)。对于复发性生殖器疱疹患者，使用局部干扰素治疗被发现有效地减少了病毒脱落的持续时间，对于男性来说，疼痛、瘙痒和结壳时间也得到了有效的减少。
Topical recombinant alpha-2 interferon treatment of recurrent genital herpes was studied in a randomized, double-blind, placebo controlled clinical trial. Three hundred and eighty-seven patients were treated at eight study centers with either interferon gel or placebo four times daily for four days. Interferon therapy caused a 26% decrease in the duration of viral shedding. For male patients, there were also significant decreases in the time to crusting (17%) and duration of pain (34%) and itching (21%). For patients with recurrent genital herpes, treatment with topical interferon was found to be effective in decreasing the duration of viral shedding and, for males, pain, itching and time to crusting.