Sphingolipid De Novo Biosynthesis: A Rheostat of Cardiovascular Homeostasis.
Sphingolipid De Novo Biosynthesis: A Rheostat of Cardiovascular Homeostasis.
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DOI：
10.1016/j.tem.2016.07.005
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发表时间：
2016-11
期刊：
影响因子：
--
通讯作者：
Di Lorenzo A
中科院分区：
文献类型：
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作者：
Sasset L;Zhang Y;Dunn TM;Di Lorenzo A
鞘磷脂既是真核膜的基本结构成分，又是调节多种生物功能的信号分子。高生物活性的脂质、神经酰胺和1-磷酸鞘氨醇已成为健康和疾病中心血管功能的重要调节因子。在这篇综述中，我们讨论了鞘磷脂，特别是神经酰胺和鞘氨醇-1-磷酸在心血管系统病理生理学中作用的最新见解。我们还重点介绍了调节丝氨酸棕榈酰转移酶的分子机制的进展，丝氨酸棕榈酰转移酶是从头合成的第一个和限速酶，重点是最近发现的丝氨酸棕榈酰转移酶的抑制剂，ORMDL和Nogo-B蛋白。了解调控这种生物合成途径的分子机制可能会导致开发新的治疗方法来治疗心血管疾病。
Sphingolipids are both, fundamental structural components of the eukaryotic membranes and signaling molecules regulating a variety of biological functions. Highly bioactive lipids, ceramide and sphingosine-1-phosphate have emerged as important regulators of cardiovascular functions in health and disease. In this review we discuss recent insights into the role of sphingolipids, particularly ceramide and sphingosine-1-phosphate, in the pathophysiology of the cardiovascular system. We also highlight advances into the molecular mechanisms regulating serine palmitoyltransferase, the first and rate-limiting enzyme of de novo biosynthesis, with an emphasis on recently discovered inhibitors of serine palmitoyltransferase, ORMDL and NOGO-B proteins. Understanding the molecular mechanisms regulating this biosynthetic pathway may lead to the development of novel therapeutic approaches for the treatment of cardiovascular diseases.
DOI：
10.2174/156727008785133809
发表时间：
2008-08-01
期刊：
Vascular disease prevention
影响因子：
--
作者：
O'Neill SM;Olympia DK;Fox TE;Brown JT;Stover TC;Houck KL;Wilson R;Waybill P;Kozak M;Levison SW;Weber N;Karavodin LM;Kester M
通讯作者：
Kester M