Impact of smoking as a risk factor for developing rheumatoid arthritis: a meta-analysis of observational studies
Impact of smoking as a risk factor for developing rheumatoid arthritis: a meta-analysis of observational studies
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DOI：
10.1136/ard.2008.096487
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发表时间：
2010-01-01
影响因子：
27.4
通讯作者：
Kumagai, S.
中科院分区：
文献类型：
--
作者：
Sugiyama, D.;Nishimura, K.;Kumagai, S.
目的：评估吸烟是否是发生类风湿性关节炎 (RA) 的危险因素。设计：荟萃分析。方法：数据来源是观察性研究，检查吸烟史与通过 Medline 和 EMBASE（从 1966 年至 2006 年 12 月）、相关书籍和参考文献检索确定的吸烟史与发生 RA 风险之间的关联。两位作者独立提取了以下信息：作者姓名、发表年份、样本量、参与者特征、比值比 (OR) 或相对风险、调整因素、研究设计和进行研究的领域。数据合成基于随机效应模型。综合效果以OR表示。结果：从433篇文献中筛选出16篇研究。对于男性，当前吸烟者和既往吸烟者的总结 OR 分别为 1.89（95% CI 1.56 至 2.28）、1.87（1.49 至 2.34）和 1.76（1.33 至 2.31）。对于类风湿因子阳性 (RF+) RA，目前吸烟者和既往吸烟者的总 OR 分别为 3.02（2.35 至 3.88）、3.91（2.78 至 5.50）和 2.46（1.74 至 3.47）。吸烟 20 包或以上的总结 OR 为 2.31（1.55 至 3.41）。对于女性来说，当前吸烟者和既往吸烟者的总 OR 值分别为 1.27（1.12 至 1.44）、1.31（1.12 至 1.54）和 1.22（1.06 至 1.40）。对于 RF+ RA，当前和过去吸烟者的总 OR 分别为 1.34（0.99 至 1.80）、1.29（0.94 至 1.77）和 1.21（0.83 至 1.77）。吸烟 20 包或以上的总结 OR 为 1.75（1.52 至 2.02）。 结论：吸烟是 RA 的危险因素，尤其是 RF+ RA 男性和重度吸烟者。
Objectives: To assess whether smoking is a risk factor for developing rheumatoid arthritis (RA).Design: Meta-analysis.Method: Data sources were observational studies that examined the association between smoking history and the risk of developing RA identified through Medline and EMBASE (from 1966 to December 2006), relevant books and a reference search. Two authors independently extracted the following: authors' names, publication year, sample size, participant characteristics, odds ratios (OR) or relative risks, adjustment factors, study design and area where the study was conducted. Data syntheses were based upon random effects model. Summarised syntheses effects were expressed by OR.Results: Sixteen studies were selected from among 433 articles. For men, summary OR for ever, current and past smokers were 1.89 (95% CI 1.56 to 2.28), 1.87 (1.49 to 2.34) and 1.76 (1.33 to 2.31), respectively. For rheumatoid factor-positive (RF+) RA, summary OR for ever, current and past smokers were 3.02 (2.35 to 3.88), 3.91 (2.78 to 5.50) and 2.46 (1.74 to 3.47), respectively. Summary OR for 20 or more pack-years of smoking was 2.31 (1.55 to 3.41). For women, summary OR for ever, current and past smokers were 1.27 (1.12 to 1.44), 1.31 (1.12 to 1.54) and 1.22 (1.06 to 1.40), respectively. For RF+ RA, summary OR for ever, current and past smokers were 1.34 (0.99 to 1.80), 1.29 (0.94 to 1.77) and 1.21 (0.83 to 1.77). Summary OR for 20 or more pack-years of smoking was 1.75 (1.52 to 2.02).Conclusion: Smoking is a risk factor for RA, especially RF+ RA men and heavy smokers.