Effects of intraarterial, intravenous, and intraluminal neurotensin on canine ileal sodium and water absorption and blood flow.
Effects of intraarterial, intravenous, and intraluminal neurotensin on canine ileal sodium and water absorption and blood flow.
复制标题
动脉内、静脉内和管腔内神经降压素对犬回肠钠和水吸收以及血流量的影响。
DOI：
10.1016/0024-3205(89)90511-0
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发表时间：
1989
期刊：
影响因子：
6.1
通讯作者：
Mailman,D
中科院分区：
文献类型：
--
作者：
Mailman,D
神经降压素是一种主要存在于回肠中并分泌到血液和管腔中的调节肽。神经降压素的生理作用尚不确定，但在某些病理状态下，神经降压素增加到可对许多器官产生影响的水平。本文研究了静脉、动脉和肠腔内注射神经降压素（0.075-7.5 μg/min）对犬回肠钠、水流量、钾分泌和血流量的影响。静脉和动脉灌注神经降压素增加净钠，钾和水的分泌，由于增加分泌流量，并增加血细胞比容。动脉内注射神经降压素并不比静脉内注射神经降压素更有效，除了刺激钾分泌。神经降压素在0.075 μg/min IA时增加钾分泌，在0.75 μg/min IA和IV时增加钠和水分泌，在7.5 μg/min IA和IV时增加红细胞压积。总血流量和吸收部位血流量以及动脉压和静脉压均未发生变化。腔内神经降压素在任何输注速率下均无影响。神经降压素可以通过局部作用在生理水平上增加钾的分泌，并且可以通过激素机制在高生理-病理水平上增加钠和水的分泌。分泌不依赖于心血管变化。
Neurotensin is a regulatory peptide which is found primarily in the ileum and is secreted into the blood and lumen. The Physiologic effects of neurotensin are uncertain but in certain pathologic states neurotensin increases to levels which can have effects on many organs. The effects of intravenous, intraarterial and intraluminal neurotensin (0.075–7.5 μg/min) on fed canine ileal sodium and water fluxes, potassium secretion, and blood flows were studied. Intravenous and intraarterial infusion of neurotensin increased net sodium, potassium, and water secretion, due to increased secretory fluxes, and increased hematocrits. Intraarterial neurotensin was not more effective than intravenous neurotensin except for stimulating potassium secretion. Neurotensin increased potassium secretion at 0.075 μg/min IA, increased sodium and water secretion at 0.75 μg/min IA and IV, and increased hematocrit at 7.5 μg/min IA and IV. Total and absorptive site blood flows and arterial and venous pressures were not changed. Intraluminal neurotensin had no effects at any infusion rate. Neurotensin can increase potassium secretion at physiologic levels by a local effect and can increase sodium and water secretion at high physiological-pathological levels through a hormonal mechanism. The secretion is not dependent on cardiovascular changes.