How well do patients take oral penicillin? A collaborative study in private practice.
How well do patients take oral penicillin? A collaborative study in private practice.
复制标题
患者服用口服青霉素的情况如何？
作者：
E. Charney;Rufus S. Bynum;Donald Eldredge;D. Frank;J. Macwhinney;Neal McNabb;A. Scheiner;E. Sumpter;H. Iker
在三个私人儿科诊所进行了一项研究，研究儿童在治疗链球菌性咽炎或中耳炎时服用口服青霉素的情况。通过黄八叠球菌培养法测定尿液中青霉素的存在，用于评估依从率。总共对 459 名患者进行了研究，其中 107 名患者接受了 5 天的治疗，352 名患者接受了 9 天的治疗。
81% 的患者在第五天按照处方服用青霉素，56% 在第九天服用。另外 13% 的人在治疗结束时服用方法不稳定。患有咽炎的儿童比患有中耳炎的儿童更有可能完成治疗。研究了许多因素，试图区分那些遵守治疗的人和不遵守治疗的人。服用率与儿童的年龄或性别、症状持续时间或医生对发病时疾病严重程度的估计无关。它与母亲对严重程度的估计、通常的医生是否开药以及儿科医生认为的母亲的某些性格特征相关。讨论了该研究对儿童使用口服疗法的影响。
A study of how well children took oral penicillin when prescribed for streptococcal pharyngitis or otitis media was conducted in three private pediatric group practices. The presence of penicillin in the urine, as determined by the Sarcina lutea culture method, was used to assess the compliance rate. A total of 459 patients were studied—107 at five days of therapy and 352 at nine days.
Eighty-one percent of the patients were taking the penicillin as prescribed on the fifth day, and 56% were taking it on the ninth day. Another 13% were erratic takers at the end of therapy. The children with pharyngitis were somewhat more likely to complete therapy than those with otitis media. A number of factors were studied in an attempt to differentiate those who complied with the therapy from those who did not. The take rate was unrelated to age or sex of the child, duration of symptoms, or doctor's estimate of severity of disease at onset. It was correlated with mother's estimate of severity, whether or not their usual doctor prescribed the medicine, and certain personality traits of the mother as perceived by the pediatrician. The implications of the study for the use of oral therapy in children are discussed.