APPLICATION OF EPR DOSIMETRY IN BONE FOR EX VIVO MEASUREMENTS OF DOSES IN RADIOTHERAPY PATIENTS
APPLICATION OF EPR DOSIMETRY IN BONE FOR EX VIVO MEASUREMENTS OF DOSES IN RADIOTHERAPY PATIENTS
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DOI：
10.1093/rpd/ncu214
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发表时间：
2014-11-01
影响因子：
1
通讯作者：
Ciesielski, B.
中科院分区：
文献类型：
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作者：
Krefft, K.;Drogoszewska, B.;Ciesielski, B.
在本研究中，三名在波兰放射治疗机构接受治疗的患者的骨骼样本被用于确定放射治疗过程中吸收的剂量。这些样本是在对因医学适应症而进行的患者的外科治疗过程中获得的。为了追溯剂量学的目的，通过以已知剂量重新照射样品来单独校准辐射诱导的EPR信号在样品中的灵敏度。在照射后6个月内取出的骨骼重建的剂量与治疗计划系统计算的剂量一致。放疗后6年摘除的骨的重建剂量比计算值低14%。
In the present study, bone samples from three patients treated in radiotherapy facilities in Poland were used for the determination of doses absorbed during radiotherapy. The samples were obtained during surgical treatments of patients performed due to medical indications. For the purpose of retrospective dosimetry, sensitivity of the radiation-induced EPR signal was individually calibrated in the samples by re-irradiation of the samples with known doses. The doses reconstructed in bones extracted within 6 months after irradiation were consistent with those calculated by treatment planning systems. The dose reconstructed in the bone removed 6 y after radiotherapy was similar to 14 % lower than the calculated one.