Exploration of different methods to assess dietary acrylamide exposure in pregnant women participating in the Norwegian Mother and Child Cohort Study (MoBa)
Exploration of different methods to assess dietary acrylamide exposure in pregnant women participating in the Norwegian Mother and Child Cohort Study (MoBa)
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DOI：
10.1016/j.fct.2008.05.020
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发表时间：
2008-08-01
影响因子：
4.3
通讯作者：
Meltzer, Helle Margrete
中科院分区：
文献类型：
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作者：
Brantsaeter, Anne Lise;Haugen, Margaretha;Meltzer, Helle Margrete
我们评估了119名挪威孕妇的丙烯酰胺饮食暴露。本研究的目的是探索三种不同的方法来估计丙烯酰胺的长期摄入量，以及是否有可能通过食物频率问卷（FFQ）来识别丙烯酰胺高暴露的孕妇。24小时尿液中以巯基尿酸代谢产物形式排泄的丙烯酰胺被用作评价工具。通过FFQ和4天称重食物日记（FD）评估摄食量。丙烯酰胺摄入量也通过基于FD后2天的概率方法估计。首先，使用挪威食品分析报告的丙烯酰胺浓度。根据FFQ、FD和概率方法，丙烯酰胺的膳食暴露量估计值分别为0.48（0.92）、0.41（0.82）和0.42（0.70）μ g/kg bw/天（中位数和95百分位数）。在非吸烟者中，以尿液代谢物形式排泄的丙烯酰胺量（中位数和95百分位数）为0.16微克/千克体重/24小时（0.50），相当于饮食暴露量约为0.30微克/千克体重/天（0.91）。通过对丙烯酰胺作为尿液代谢物排泄的线性回归分析，确定了脆面包和薯片是显著的独立预测因子，沿着的还有食用油和洋葱/大蒜。通过FFQ、FD和概率模型计算的丙烯酰胺饮食暴露量具有可比性。FFQ丙烯酰胺估计值与尿丙烯酰胺代谢物水平的比较表明，MoBa FFQ能够识别出高饮食丙烯酰胺暴露的参与者。我们的研究结果有助于未来在MoBa研究中对丙烯酰胺暴露和健康结果的研究。(c)2008爱思唯尔有限公司保留所有权利。
We assessed dietary exposure to acrylamide in 119 pregnant Norwegian women. The aim of the study was to explore three different methods for estimation of long-term intake of acrylamide and whether it is possible by a food frequency questionnaire (FFQ) to identify pregnant women with high exposure to acrylamide. Acrylamide excreted as mercapturic acid metabolites in 24-h urine was used as an evaluation tool. Food consumption was assessed by an FFQ and by a 4-day weighed food diary (FD). Acrylamide intake was also estimated by a probabilistic approach based on 2 days from the FD. Primarily, acrylamide concentrations reported from analyses of Norwegian foods were used. The dietary exposure to acrylamide estimated as mu g/kg bw/day (median and 95 percentile) was 0.48 (0.92) by the FFQ, 0.41 (0.82) by the FD and 0.42 (0.70) by the probabilistic approach. The amount of acrylamide excreted as Urinary metabolites (median and 95 percentile)was 0.16 mu g/kg bw/24-h (0.50) in non-smokers, corresponding to a dietary exposure of approximately 0.30 mu g/kg bw/day (0.91). Linear regression of acrylamide excreted as urinary metabolites identified Crisp bread and potato Crisps as significant independent predictors, along with cooking oil and onion/garlic. Dietary exposure to acrylamide calculated by FFQ, FD and probabilistic modelling were comparable. The comparison of FFQ acrylamide estimates with levels Of urinary acrylamide metabolites showed that the MoBa FFQ was able to identify participants with high dietary acrylamide exposure. Our findings facilitate future studies on acrylamide exposure and health outcomes in the MoBa study. (c) 2008 Elsevier Ltd. All rights reserved.