Acute colitis enhances responsiveness of lumbosacral spinal neurons to colorectal distension in rats.
Acute colitis enhances responsiveness of lumbosacral spinal neurons to colorectal distension in rats.
复制标题
急性结肠炎增强大鼠腰骶脊髓神经元对结直肠扩张的反应性。
DOI：
10.1007/s10620-007-9835-z
复制
发表时间：
2008
影响因子：
3.1
通讯作者：
Foreman,RD
中科院分区：
文献类型：
--
作者：
Qin,C;Malykhina,AP;Akbarali,HI;Greenwood-VanMeerveld,B;Foreman,RD
Aim of this study was to examine excitability and responsiveness of lumbosacral spinal neurons to colorectal distension (CRD) in rats with colitis induced by dextran sulphate sodium (DSS). Extracellular potentials of single L6-S2 spinal neurons were recorded in pentobarbital anesthetized and paralyzed rats. Results showed that 40/154 (26%) and 53/156 (34%) neurons responded to noxious CRD (80 mmHg, 20 s) in DSS-treated and control animals, respectively. Neurons with long-lasting and low-threshold excitatory responses to CRD were more frequently encountered in DSS-treated than in control groups (P< 0.05). The mean maximal excitatory responses of neurons to noxious CRD in DSS-treated animals were significantly greater and the duration of responses was longer than those in control animals (P< 0.05). It was suggested that lumbosacral spinal neurons with colorectal input had increased excitability and responsiveness following colitis, which might play an important role in development of colonic hypersensitivity and viscerosomatic referred pain.
