Y chromosome probe p49a detects complex PvuII haplotypes and many new TaqI haplotypes in southern African populations.
Y chromosome probe p49a detects complex PvuII haplotypes and many new TaqI haplotypes in southern African populations.
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Y 染色体探针 p49a 可检测南部非洲人群中复杂的 PvuII 单倍型和许多新的 TaqI 单倍型。
DOI：
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发表时间：
1992
影响因子：
9.8
通讯作者：
T. Jenkins
中科院分区：
文献类型：
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作者：
A. Spurdle;T. Jenkins
Y-特异性49 a/TaqI单倍型确定了831人来自21个不同的南部非洲人口。共观察到31个新的单倍型，其中一些包含新的等位基因或等位基因变体。除了CpG突变之外，复制还涉及某些等位基因变体的产生。使用49 a/TaqI单倍型频率计算的人群之间的遗传距离的聚类分析，揭示了非洲和非非洲人群之间的基本分裂。杂种群体与高加索群体聚在一起，表明雄性基因流已经从后者进入前者。黑人和科伊桑人群体的聚集并不是从已知的语言亲缘关系中所期望的。这表明，49 a/TaqI单倍型分析，这些人口是不够敏感，以区分许多人口。Y-特异性49 a/PvuII多态性进行了研究，在127个来自南部非洲人群，和17个多态性片段的大小从3.6 kb到大于48 kb的范围内进行了鉴定。共观察到53个PvuII单倍型，对应于只有30个TaqI单倍型。这两种多态性之间的相关性似乎很差。
Y-specific 49a/TaqI haplotypes were determined for 831 individuals drawn from 21 different southern African populations. A total of 31 new haplotypes were observed, some of which contained new alleles or allelic variants. Duplication, in addition to CpG mutation, is implicated in the generation of certain allelic variants. Cluster analysis of genetic distances between the populations, calculated using the 49a/TaqI haplotype frequencies, revealed a basic split between African and non-African populations. Hybrid groups cluster with the caucasoid groups, indicating that male gene flow has occurred from the latter into the former. Clustering of the negroid and Khoisan groups is not what might have been expected from the known linguistic affinities. It is suggested that the 49a/TaqI haplotype analysis of these populations is not sufficiently sensitive to distinguish between many of the populations. The Y-specific 49a/PvuII polymorphism was studied in 127 individuals from southern African populations, and 17 polymorphic fragments ranging in size from 3.6 kb to greater than 48 kb were identified. A total of 53 PvuII haplotypes were observed, corresponding to only 30 TaqI haplotypes. There appears to be poor correlation between the two polymorphisms.