The Relationship Between Childhood Psychosocial Stressor Level and Telomere Length: A Meta-Analysis.
The Relationship Between Childhood Psychosocial Stressor Level and Telomere Length: A Meta-Analysis.
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DOI：
10.4081/hpr.2017.6378
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发表时间：
2017-05-16
影响因子：
2
通讯作者：
Epel ES
中科院分区：
文献类型：
--
作者：
Hanssen LM;Schutte NS;Malouff JM;Epel ES
这项荟萃分析调查了儿童心理社会应激源水平和端粒长度之间的关系，端粒长度是一个重要的健康生物标志物。这项包括27个样本和16,238名参与者的荟萃分析发现，在平均年龄为42岁的研究中，童年时期压力水平较高的人与较短的端粒长度之间存在-0.08的显著关联。调节分析显示，效应大小的方向有明显增大的趋势，应激源和端粒测量之间的时间越短。主持人分析显示，对于使用分类方法评估儿童应激源水平的研究，以及使用qPCR而不是Southern印迹方法完成的分析，效果大小明显更高。无论研究是检测白细胞还是口腔细胞，无论研究是否通过基于记忆的回忆与档案记录评估儿童应激源水平，以及研究是否控制了年龄、性别或其他变量，都没有显著缓和效应大小。这一结果聚焦于童年时期的事件，补充了之前的发现，即感知到的压力和负面情绪与端粒长度有关。
This meta-analysis examined the association between the level of childhood psychosocial stressors and telomere length, an important health biomarker. The meta-analysis, including 27 samples and 16,238 participants, found a significant association of -0.08 between a higher level of childhood stressors and shorter telomere length at a mean age of 42 across studies. Moderator analyses showed a trend in the direction of effect sizes being significantly larger with shorter times between the stressors and telomere measurement. Moderator analyses showed significantly higher effect sizes for studies that used a categorical method for assessing child stressor level and for assays completed with qPCR rather than with the Southern blot method. There was no significant moderation of effect size by whether study assayed leukocytes or buccal cells, whether the study assessed child stressor level by memory-based recall versus archival records, and whether the study controlled for age, sex, or additional variables. The results, focused on childhood events, add to prior findings that perceived stress and negative emotions are associated with telomere length.