NFAT5 in cellular adaptation to hypertonic stress - regulations and functional significance.
NFAT5 in cellular adaptation to hypertonic stress - regulations and functional significance.
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DOI：
10.1186/1750-2187-8-5
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发表时间：
2013-04-23
影响因子：
--
通讯作者：
Ko BC
中科院分区：
文献类型：
--
作者：
Cheung CY;Ko BC
活化T细胞核因子-5（NFAT 5），也称为OREBP或TonEBP，是活化T细胞转录因子家族的核因子成员。它也是哺乳动物中唯一已知的张力调节转录因子。NFAT 5最初因其在高渗肾内髓质中的作用而闻名，用于协调遗传程序以恢复细胞内稳态。然而，新出现的证据表明，NFAT 5可能发挥更多样化的功能作用，包括在血压调节和自身免疫性疾病的发展中发挥关键作用。尽管NFAT 5在生理学和疾病中的重要性日益增加，但我们对其活性如何调节的理解仍然非常有限。此外，张力的变化如何通过NFAT 5转化为功能输出仍然是难以捉摸的。本文就NFAT 5在渗透胁迫适应中的作用及其信号通路的研究进展作一综述。
The Nuclear Factor of Activated T Cells-5 (NFAT5), also known as OREBP or TonEBP, is a member of the nuclear factors of the activated T cells family of transcription factors. It is also the only known tonicity-regulated transcription factor in mammals. NFAT5 was initially known for its role in the hypertonic kidney inner medulla for orchestrating a genetic program to restore the cellular homeostasis. Emerging evidence, however, suggests that NFAT5 might play a more diverse functional role, including a pivotal role in blood pressure regulation and the development of autoimmune diseases. Despite the growing significance of NFAT5 in physiology and diseases, our understanding of how its activity is regulated remains very limited. Furthermore, how changes in tonicities are converted into functional outputs via NFAT5 remains elusive. Therefore, this review aims to summarize our current knowledge on the functional roles of NFAT5 in osmotic stress adaptation and the signaling pathways that regulate its activity.