B cells in chronic graft-versus-host disease.
B cells in chronic graft-versus-host disease.
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DOI：
10.1016/j.bbmt.2014.10.029
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发表时间：
2015-01
期刊：
影响因子：
--
通讯作者：
Ritz J
中科院分区：
文献类型：
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作者：
Sarantopoulos S;Blazar BR;Cutler C;Ritz J
慢性移植物抗宿主病（cGVHD）一直是同种异体造血干细胞移植（HSCT）的常见并发症。与几乎完全由供体T细胞介导的急性GVHD不同，cGVHD的免疫病理更为复杂，并且发现供体B细胞也起重要作用。最近来自几个实验室的研究增强了我们对供体B细胞如何导致这种临床综合征的理解，这带来了新的治疗机会。在这里，Sarantopoulos博士回顾了cGVHD患者持续B细胞激活和B细胞耐受性丧失的一些重要机制。Blazar博士介绍了最近在临床前模型中进行的研究，这些研究已经确定了可能有效预防或治疗cGVHD的新型B细胞定向药物。一些B细胞定向疗法已经在cGVHD患者中进行了测试，卡特勒博士回顾了这些研究的结果，证明了这种方法的潜在功效。在患者机制研究和临床前模型的支持下，针对cGVHD的新的B细胞定向疗法现在将在临床试验中进行评估。
Chronic graft versus host disease (cGVHD) continues to be a common complication of allogeneic hematopoietic stem cell transplantation (HSCT). Unlike acute GVHD, which is mediated almost entirely by donor T cells, the immune pathology of cGVHD is more complex and donor B cells have also been found to play an important role. Recent studies from several laboratories have enhanced our understanding of how donor B cells contribute to this clinical syndrome and this has led to new therapeutic opportunities. Here, Dr. Sarantopoulos reviews some of the important mechanisms responsible for persistent B cell activation and loss of B cell tolerance in patients with cGVHD. Dr. Blazar describes recent studies in preclinical models that have identified novel B cell directed agents that may be effective for prevention or treatment of cGVHD. Some B cell directed therapies have already been tested in patients with cGVHD and Dr. Cutler reviews the results of these studies documenting the potential efficacy of this approach. Supported by studies mechanistic studies in patients and preclinical models, new B cell directed therapies for cGVHD will now be evaluated in clinical trials.
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