Molecular mechanism of intestinal permeability: interaction at tight junctions
Molecular mechanism of intestinal permeability: interaction at tight junctions
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DOI：
10.1039/b800402a
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发表时间：
2008-01-01
影响因子：
--
通讯作者：
Hirata, Takashi
中科院分区：
文献类型：
--
作者：
Hossain, Zakir;Hirata, Takashi
肠道屏障在人类营养物质和大分子的运输中起着关键作用。与此同时，它必须提供对有害大分子和微生物的有效屏障。紧密连接（TJ）是这种屏障的重要组成部分。质膜的连接复合物不仅是细胞旁转运中的上皮屏障或阻止质膜中扩散的屏障，而且还包含参与信号转导和维持生理上皮细胞状态的蛋白质。封闭蛋白、紧密连接蛋白、连接粘附分子和科萨基病毒和腺病毒受体是TJ的主要成分。本文重点介绍了TJ的结构和功能，以及通过TJ渗透过程中发生的分子相互作用。
The intestinal barrier plays a critical role in humans in the transport of nutrients and macromolecules. At the same time, it has to provide an effective barrier to harmful macromolecules and microorganisms. The tight junction (TJ) is an essential component of this barrier. The junctional complexes of the plasma membrane are not simply epithelial barriers in paracellular transport or barriers preventing diffusion in the plasma membrane, but also contain proteins involved in signal transduction and the maintenance of the physiological epithelial cell state. Occludin, claudin, junctional adhesion molecules, and the coxsackie virus and adenovirus receptor are the major components of TJs. This article highlights the structure and function of TJs as well as the molecular interactions occurring during permeation through TJs.