Rapidly degrading and mussel-inspired multifunctional carboxymethyl chitosan/montmorillonite hydrogel for wound hemostasis
Rapidly degrading and mussel-inspired multifunctional carboxymethyl chitosan/montmorillonite hydrogel for wound hemostasis
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DOI：
10.1016/j.ijbiomac.2023.124960
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发表时间：
2023-05-26
影响因子：
8.2
通讯作者：
Gu, Yubei
中科院分区：
文献类型：
--
作者：
Ouyang, Yongliang;Zhao, Yizhou;Gu, Yubei
传统使用蒙脱石止血材料的方法由于容易在创面上移位而影响止血效果。以改性海藻酸盐、聚乙烯吡咯烷酮（PVP）和羧甲基壳聚糖为原料，制备了基于氢键和席夫碱键的多功能生物止血水凝胶（CODM）。氨基改性蒙脱土通过与羧甲基壳聚糖和氧化海藻酸盐的羧基形成氨基键而均匀地分散在水凝胶中。儿茶酚基团、-CHO、PVP能与组织表面形成氢键，使组织粘连牢固，起到伤口止血作用。蒙脱石- nh2的加入进一步提高了止血能力，使其优于市售止血材料。此外，其光热转化能力（来源于聚多巴胺）与酚羟基、醌基、质子化氨基协同作用，在体外和体内均能有效杀灭细菌。CODM水凝胶具有良好的体外和体内生物安全性和降解率，具有抗炎、抗菌和止血等特性，在急诊止血和智能伤口管理方面具有广阔的应用前景。
The conventional method of using montmorillonite hemostatic materials affects the hemostatic effect due to easy dislodgement on the wound surface. In this paper, a multifunctional bio-hemostatic hydrogel (CODM) was prepared based on hydrogen bonding and Schiff base bonding using modified alginate, polyvinylpyrrolidone (PVP), and carboxymethyl chitosan. The amino group-modified montmorillonite was uniformly dispersed in the hydrogel by its amido bond formation with the carboxyl groups of carboxymethyl chitosan and oxidized alginate. The catechol group, -CHO, and PVP can form hydrogen bonds with the tissue surface to afford the firm tissue adhesion to afford the wound hemostatic. The addition of montmorillonite-NH2 further improves the hemostatic ability, making it better than commercial hemostatic materials. Moreover, the photothermal conversion ability (derived from the polydopamine) was synergized with the phenolic hydroxyl group, quinone group, and the protonated amino group to effectively kill the bacteria in vitro and in vivo. Based on its in vitro and in vivo biosafety and satisfactory degradation ratio anti-inflammatory, antibacterial, and hemostatic properties, the CODM hydrogel holds promising potential for emergency hemostasis and intelligent wound management.