MORPHOGENS IN VERTEBRATE DEVELOPMENT - HOW DO THEY WORK
MORPHOGENS IN VERTEBRATE DEVELOPMENT - HOW DO THEY WORK
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DOI：
10.1002/bies.950170202
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发表时间：
1995-02-01
期刊：
影响因子：
4
通讯作者：
COOKE, J
中科院分区：
文献类型：
--
作者：
COOKE, J
关键物质的浓度梯度可能会控制发育模式，甚至在复杂生物体的胚胎中也是如此。这种观点已经存在了很长时间，但大多以模糊的形式存在。25年前，关于这种梯度如何起作用的清晰、可实验验证的观点被阐明，最近形态学梯度原理被证明是果蝇开始形成模式的基础。它对脊椎动物的发育也很重要吗？最近的四篇论文将实验提升到了一个新的水平（1-4），同时也表明了确定这一机制的精确形式是多么困难。
The idea that concentration gradients of crucial substances might control the pattern of development, even in the embryos of complex organisms, has been around for a long time, but mostly in obscure forms. Twenty five years ago clear, experimentally testable ideas about how such gradients might work were enunciated, and more recently the morphogen gradient principle was shown to underlie the beginnings of patterning in Drosophila. Is it also central to vertebrate development? Four recent papers raise experimentation to a new level((1-4)), while showing how difficult it might be to pin down the precise form of the mechanism.