ORAL MANIFESTATIONS ASSOCIATED WITH HIV-RELATED DISEASE AS MARKERS FOR IMMUNE SUPPRESSION AND AIDS
ORAL MANIFESTATIONS ASSOCIATED WITH HIV-RELATED DISEASE AS MARKERS FOR IMMUNE SUPPRESSION AND AIDS
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DOI：
10.1016/0030-4220(94)90195-3
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发表时间：
1994-04-01
影响因子：
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通讯作者：
SALKIN, LM
中科院分区：
文献类型：
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作者：
GLICK, M;MUZYKA, BC;SALKIN, LM
背景口腔病变是HIV相关疾病的常见表现，但其在预测HIV感染者免疫抑制中的意义尚不清楚。对454名到牙科门诊就诊的患者进行口腔检查。CD 4+细胞计数在检查后2个月内获得。在具有特异性病变和CD 4+细胞计数低于200 Cells/mm 3的人中，相应的平均CD 4+细胞计数和预测值对于念珠菌病为149.5个细胞/mm 3和69.9%，对于口腔毛状白斑为143.3个细胞/mm 3和70.1%，对于口干症为126.0个细胞/mm 3和69.4%，单纯疱疹病毒长期感染者为98.7 cells/mm ~ 3，阳性率为87.0%;卡波西肉瘤为66.6 cells/mm ~ 3，阳性率为93.6%;平均CD 4+细胞计数随着不同并发病变数量的增加而下降。在HIV感染者中，特定口腔表现的存在和不同并发口腔内病变的数量与严重的免疫抑制和艾滋病有关。口腔检查是早期识别疾病进展和全面评估艾滋病毒感染者的重要组成部分。
Background. Oral lesions are common findings in HIV-related disease, but little is known about their significance in predicting immune suppression among a representative group of HIV-infected persons.Methods. Oral examinations were performed on 454 patients who came to an outpatient dental clinic for dental care. CD4+ cell counts were obtained within 2 months of the examination.Results. In persons with a specific lesion and a CD4+ cell count below 200 CellS/mm3 the corresponding mean CD4+ cell counts and predictive values were 149.5 cells/mm3 and 69.9% for candidiasis, 143.3 cells/mm3 and 70.1% for oral hairy leukoplakia, 126.0 cells/mm3 and 69.4% for xerostomia, 51.8 cells/mm3 and 95.1% for necrotizing ulcerative periodontitis, 98.7 cellS/mm3 and 87.0% for long-standing herpes simplex virus infections, 66.6 cells/MM3 and 93.6% for Kaposi's sarcoma, and 33.7 cells/mm3 and 100% for major aphthous ulcers. The mean CD4+cell count declined with increased numbers of different concurrent lesions.Conclusions. The presence of specific oral manifestations and the number of different concurrent intraoral lesions among HIV-infected persons are associated with severe immune suppression and AIDS. Oral examinations are an essential component for early recognition of disease progression and comprehensive evaluation of HIV-infected patients.