Elevated plasma levels of Th17-related cytokines are associated with increased risk of atrial fibrillation.
Elevated plasma levels of Th17-related cytokines are associated with increased risk of atrial fibrillation.
复制标题
血浆 Th17 相关细胞因子水平升高与心房颤动风险增加相关
DOI：
10.1038/srep26543
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发表时间：
2016-05-20
影响因子：
4.6
通讯作者：
Zhong L
中科院分区：
文献类型：
--
作者：
Wu N;Xu B;Liu Y;Chen X;Tang H;Wu L;Xiang Y;Zhang M;Shu M;Song Z;Li Y;Zhong L
我们使用倾向评分匹配进行了一项匹配病例对照研究，以评估Th 17相关细胞因子（包括白细胞介素（IL）17 A（IL-17 A）、IL-17 F、IL-21、IL-22和IL-6，沿着干扰素-γ（IFN-γ）、IL-10、IL-9和IL-4）与AF风险的相关性。使用Luminex xMAP测定法测量血浆细胞因子水平。房颤患者血浆中各种细胞因子水平均显著高于对照组（P < 0.05），且各细胞因子之间高度相关（P < 0.01）。多变量条件Logistic回归分析显示，IL-17 A、IL-17 F、IL-21、IL-22、IFN-γ、IL-10、IL-9和IL-6血浆水平升高与AF风险显著相关，与潜在混杂因素无关。阵发性和慢性房颤患者血浆细胞因子水平无显著差异。IL-17 A、IL-21、IL-10、IL-6水平与左房内径呈正相关，IL-17 F水平与左室射血分数呈负相关（P < 0.05）。Th 17相关细胞因子的血浆水平升高与AF风险增加独立相关;因此，Th 17相关细胞因子可能参与AF的发病机制。
We performed a matched case-control study using a propensity score matching, to assess the association of Th17-related cytokines, including interleukin (IL) 17A (IL-17A), IL-17F, IL-21, IL-22 and IL-6, along with interferon-γ (IFN-γ), IL-10, IL-9, and IL-4, with the risk of AF. A total of 336 patients with AF were matched 1:1 with patients without AF. Plasma levels of cytokines were measured using Luminex xMAP assays. The plasma levels of all examined cytokines were significantly higher in AF patients than controls (P < 0.05), and these cytokines were highly correlated with each other (P < 0.01). A multivariate conditional logistic regression analysis showed that elevated plasma levels of IL-17A, IL-17F, IL-21, IL-22, IFN-γ, IL-10, IL-9 and IL-6 were significantly associated with AF risk independently of potential confounders. There were no significant differences in plasma levels of examined cytokines between paroxysmal and chronic AF patients. IL-17A, IL-21, IL-10 and IL-6 levels were positively correlated with left atrial diameter; IL-17F level was negatively correlated with left ventricle ejection fraction among AF patients (P < 0.05). Elevated plasma levels of Th17-related cytokines were independently associated with increased an risk of AF; hence, Th17-related cytokines may be involved in the pathogenesis of AF.