Immune System Cooperatively Supports Endocrine System-Primed Embryo Implantation
Immune System Cooperatively Supports Endocrine System-Primed Embryo Implantation
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DOI：
10.1274/jmor.26.122
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发表时间：
2009-12
期刊：
影响因子：
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通讯作者：
H. Fujiwara;A. Ideta;Y. Araki;Y. Takao;Yukiyasu Sato;N. Tsunoda;Y. Aoyagi;I. Konishi
中科院分区：
文献类型：
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作者：
H. Fujiwara;A. Ideta;Y. Araki;Y. Takao;Yukiyasu Sato;N. Tsunoda;Y. Aoyagi;I. Konishi
摘要： 子宫内膜上皮的附着是人类胚胎的一个重要过程。尽管人们普遍认为这一过程很大程度上受到内分泌系统的调节，但确切的分子机制仍不清楚。最近的证据表明，免疫细胞积极促进胚胎着床的建立。据此，我们发现外周血免疫细胞积极影响母体子宫内膜的分化，以促进妊娠早期胚胎着床。根据这些发现，我们提出了一个新概念，即循环免疫细胞是胚胎植入的重要调节因子。最近，接受体外受精和胚胎移植治疗的患者的植入失败受到越来越多的关注。根据我们的假设，我们成功开发了一种利用自体外周血免疫细胞治疗植入失败的新疗法。这些发现表明，通过免疫系统的支持机制促进胚胎植入，并将在辅助生殖技术领域发挥作用。
Abstract: Attachment to endometrial epithelium is an essential process for human embryos. Although it is widely accepted that this process is largely regulated by the endocrine system, the precise molecular mechanism(s) remains unclear. Recent evidence suggests that immune cells actively contribute to the establishment of embryo implantation. In accordance with this, we found that peripheral blood immune cells positively affect the differentiation of maternal endometrium to facilitate embryo implantation during early pregnancy. From these findings, we propose a novel concept that circulating immune cells are important regulators of embryo implantation. Lately, implantation failure in patients treated with in vitro fertilization and embryo transfer has received increasing attention. Based on our hypothesis, we have successfully developed a new therapy for implantation failure using autologous peripheral blood immune cells. These findings suggest that supportive mechanisms via the immune system facilitate embryo implantation and will be useful in the field of assisted reproductive technology.