HLA and alcoholic cirrhosis.
HLA and alcoholic cirrhosis.
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HLA 和酒精性肝硬化。
DOI：
10.1111/j.1399-0039.1982.tb01410.x
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
I. Mackay
中科院分区：
文献类型：
--
作者：
B. Tait;I. Mackay
57例酒精性肝硬化患者HLA-DR_2基因频率为47.4%，而119例正常人为26.1%，43例自身免疫型慢性活动性肝炎（CAH）为14.0%。HLA-DR 3在三组中的频率也不同，分别为24.6%、31.9%和74.4%。酒精性肝硬化和慢性活动性肝炎患者HLA-DR谱的巨大差异表明了这两种肝病易感性的免疫遗传差异。
In fifty-seven patients with alcoholic cirrhosis the frequency of HLA-DR2 was found to be 47.4%, in contrast to 26.1% in 119 normal subjects and 14.0% in 43 cases of autoimmune-type chronic active hepatitis (CAH). The frequencies of HLA-DR3 in the three respective groups also differed, being 24.6%, 31.9% and 74.4%. The greatly differing HLA-DR profiles in alcoholic cirrhosis and CAH point to immunogenetic differences in predisposition to these two liver diseases.