Cellular RNA hubs: friends and foes of plant viruses.
Cellular RNA hubs: friends and foes of plant viruses.
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细胞 RNA 中枢：植物病毒的朋友和敌人。
DOI：
10.1094/mpmi-06-19-0161-fi
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
Richard Kormelink
中科院分区：
文献类型：
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作者：
Min Xu;Magdalena J.Mazur;Xiaorong Tao;Richard Kormelink
RNA颗粒是广泛存在于真核细胞中的一种动态细胞灶，在细胞生长发育、免疫和应激反应中起着重要作用。可以区分不同类型的颗粒，每种颗粒都具有特定的功能，并在例如RNA转录、修饰、加工、衰变、翻译和停滞中发挥作用。通过交流和交换（共享）组件，它们在细胞中形成了一个大型的调节网络。据报道，病毒与这些细胞质或细胞核颗粒中的一种或多种相互作用，并且作为前病毒以使能和支持病毒感染并促进病毒移动，或者作为抗病毒剂，保护和/或清除宿主免受病毒感染。本文综述了细胞质和核RNA颗粒及其与病毒感染的相互作用的概述和最新进展，首先在动物系统中，并作为一个前奏的状态和目前的发展，植物病毒，这方面的研究还不够好。
RNA granules are dynamic cellular foci that are widely spread in eukaryotic cells and play essential roles in cell growth and development, immune and stress responses. Different types of granules can be distinguished, each with a specific function and playing a role in e.g. RNA transcription, modification, processing, decay, translation and arrest. By means of communication and exchange of (shared) components they form a large regulatory network in cells. Viruses have been reported to interact with one or more of these either cytoplasmic or nuclear granules, and act either pro-viral to enable and support viral infection and facilitate viral movement, or antiviral, protecting and/or clearing hosts from viral infection. This review describes an overview and recent progress on cytoplasmic and nuclear RNA granules and their interplay with virus infection, first in animal systems and as a prelude to the status and current developments on plant viruses, which have been less well studied on this so far.