Brain-derived neurotrophic factor differentially modulates excitability of two classes of hippocampal output neurons.
Brain-derived neurotrophic factor differentially modulates excitability of two classes of hippocampal output neurons.
复制标题
DOI：
10.1152/jn.00186.2016
复制
发表时间：
2016-08-01
影响因子：
2.5
通讯作者：
Kaczorowski CC
中科院分区：
文献类型：
--
作者：
Graves AR;Moore SJ;Spruston N;Tryba AK;Kaczorowski CC
我们发现 BDNF 介导两类下锥体神经元（EB 和 LB 神经元）内在神经元兴奋性的急性和持久变化。尽管 BDNF 在这两种细胞类型的突触可塑性诱导中发挥相似的作用，但它对 EB 和 LB 神经元的内在兴奋性和爆发可塑性产生差异性和双向影响。这些细胞类型特异性效应代表了 BDNF 影响海马体完善的信息存储功能的新途径。脑源性神经营养因子（BDNF）在海马依赖性学习和记忆中发挥着重要作用。通常，这归因于 CA1 区域神经元兴奋性和突触可塑性的增强作用。然而，下托中的锥体神经元形成了将海马信息传递到大脑其他区域的主要传出通路，但 BDNF 对这些神经元的影响仍未被探索。我们提出的新数据表明 BDNF 以比之前建议的更为复杂的方式调节神经元兴奋性和细胞可塑性。皮下锥体神经元可分为两大类，它们具有不同的电生理和形态特性、诱导可塑性的不同要求以及不同的海马外投射。我们发现 BDNF 增加一类皮下锥体神经元的兴奋性，但降低另一类的兴奋性。此外，虽然内源性 BDNF 对于两种细胞类型的突触可塑性的诱导都是必需的，但 BDNF 增强了一类锥体神经元的内在可塑性，但抑制了另一类锥体神经元的内在可塑性。总而言之，这些数据表明 BDNF 信号传导具有新的作用，因为它似乎可以动态地双向调节海马信息向大脑不同区域的输出。
We show that BDNF mediates acute and long-lasting changes in intrinsic neuronal excitability in two classes of subicular pyramidal neurons (EB and LB neurons). Although BDNF plays similar roles in the induction of synaptic plasticity in these two cell types, it differentially and bidirectionally affects intrinsic excitability and burst plasticity in EB and LB neurons. These cell type-specific effects represent new avenues by which BDNF can influence the well-established information storage function of the hippocampus. Brain-derived neurotrophic factor (BDNF) plays an important role in hippocampus-dependent learning and memory. Canonically, this has been ascribed to an enhancing effect on neuronal excitability and synaptic plasticity in the CA1 region. However, it is the pyramidal neurons in the subiculum that form the primary efferent pathways conveying hippocampal information to other areas of the brain, and yet the effect of BDNF on these neurons has remained unexplored. We present new data that BDNF regulates neuronal excitability and cellular plasticity in a much more complex manner than previously suggested. Subicular pyramidal neurons can be divided into two major classes, which have different electrophysiological and morphological properties, different requirements for the induction of plasticity, and different extrahippocampal projections. We found that BDNF increases excitability in one class of subicular pyramidal neurons yet decreases excitability in the other class. Furthermore, while endogenous BDNF was necessary for the induction of synaptic plasticity in both cell types, BDNF enhanced intrinsic plasticity in one class of pyramidal neurons yet suppressed intrinsic plasticity in the other. Taken together, these data suggest a novel role for BDNF signaling, as it appears to dynamically and bidirectionally regulate the output of hippocampal information to different regions of the brain.