Spleen versus pancreas:: strict control of organ interrelationship revealed by analyses of Bapx1-/- mice
Spleen versus pancreas:: strict control of organ interrelationship revealed by analyses of Bapx1-/- mice
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DOI：
10.1101/gad.381906
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发表时间：
2006-08-15
影响因子：
10.5
通讯作者：
Ahlgren, Ulf
中科院分区：
文献类型：
--
作者：
Asayesh, Amir;Sharpe, James;Ahlgren, Ulf
在胰腺发育的早期阶段，对脾脏有贡献的间充质覆盖在背侧胰腺内胚层上。在这里，我们表明，脾间充质和胰腺之间的相互作用进行通过一个高度协调的形态发生程序。形态发生的破坏，如发生在Bapx 1（Nkx3.2）（-/-）胚胎，导致这些组织转化为组织良好的，异位肠样结构。Bapx 1起着重要的组织作用，影响脾脏和胰腺的位置和分离，以防止这种化生转化。在采用野生型胰腺内胚层和脾间充质的器官培养物中也发生了类似的转化，揭示了胰腺的发育可塑性，以及两种器官发育所需的组织相互作用的精确空间和时间控制。
During early stages of pancreatic development, the mesenchyme that contributes to the spleen overlies the dorsal pancreatic endoderm. Here, we show that interactions between splenic mesenchyme and pancreas proceed via a highly orchestrated morphogenetic program. Disruption of morphogenesis, as occurs in the Bapx1(Nkx3.2)(-/-) embryo, results in transformation of these tissues into well-organized, ectopic gut-like structures. Bapx1 plays a crucial organizing role effecting position and separation of the spleen and pancreas to prevent this metaplastic transformation. Similar transformations occur in organ cultures employing wild-type pancreatic endoderm and spleen mesenchyme, revealing the developmental plasticity of the pancreas and that precise spatial and temporal control of tissue interactions are required for development of both organs.