Detailed Vascular Anatomy of the Human Retina by Projection-Resolved Optical Coherence Tomography Angiography.
Detailed Vascular Anatomy of the Human Retina by Projection-Resolved Optical Coherence Tomography Angiography.
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DOI：
10.1038/srep42201
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发表时间：
2017-02-10
影响因子：
4.6
通讯作者：
Huang D
中科院分区：
文献类型：
--
作者：
Campbell JP;Zhang M;Hwang TS;Bailey ST;Wilson DJ;Jia Y;Huang D
光学相干断层血管造影（OCTA）是一种无创的视网膜和脉络膜循环的三维成像方法。然而，血管深度识别受限于浅层血管将血流信号伪影投射到更深层。投影分辨（PR） OCTA算法通过去除投影伪影来提高深度分辨率，同时保留深层真实血管的原位血流信号。这项新技术使我们能够以比以前更好的深度分辨率研究体内正常的视网膜血管系统。我们对正常人志愿者的调查显示，视网膜上存在2到4个不同的血管丛，这取决于相对视盘和中央窝的位置。这些视网膜丛和连接层的血管形态与先前的组织学研究一致。基于这些数据，我们提出了一种改进的命名和分割边界系统，用于详细的三维视网膜血管解剖。这可以作为未来研究正常视网膜解剖、血管畸形、非灌注和新生血管的基础。
Optical coherence tomography angiography (OCTA) is a noninvasive method of 3D imaging of the retinal and choroidal circulations. However, vascular depth discrimination is limited by superficial vessels projecting flow signal artifact onto deeper layers. The projection-resolved (PR) OCTA algorithm improves depth resolution by removing projection artifact while retaining in-situ flow signal from real blood vessels in deeper layers. This novel technology allowed us to study the normal retinal vasculature in vivo with better depth resolution than previously possible. Our investigation in normal human volunteers revealed the presence of 2 to 4 distinct vascular plexuses in the retina, depending on location relative to the optic disc and fovea. The vascular pattern in these retinal plexuses and interconnecting layers are consistent with previous histologic studies. Based on these data, we propose an improved system of nomenclature and segmentation boundaries for detailed 3-dimensional retinal vascular anatomy by OCTA. This could serve as a basis for future investigation of both normal retinal anatomy, as well as vascular malformations, nonperfusion, and neovascularization.