A Device to Predict Short-Term Healing Outcome of Chronic Wounds.
A Device to Predict Short-Term Healing Outcome of Chronic Wounds.
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预测慢性伤口短期愈合结果的装置。
DOI：
10.1089/wound.2019.1064
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发表时间：
2020
影响因子：
4.9
通讯作者：
Tang,Liping
中科院分区：
文献类型：
--
作者：
Vu,Hong;Nair,Ashwin;Tran,Lan;Pal,Suvra;Senkowsky,Jon;Hu,Wenjing;Tang,Liping
目的：虽然大量研究表明伤口 pH 环境的调查可以表明伤口愈合活动，但尚不清楚伤口碱度是否可以作为不愈合伤口的预后指标。目前可用的系统无法可靠地评估伤口的 pH 环境，而这正是本研究的目的。方法：开发了一种一次性设备 DETEC®pH，并对其特征进行了描述，该设备能够通过将新鲜回收的伤口敷料压在其测试表面上来绘制伤口碱度图。通过比较 pH 测量后伤口的碱度和尺寸减小率（约 7 天），我们评估了伤口碱度预测随后短期伤口尺寸减小率的能力。结果：该设备在确定浸泡在伤口敷料上的模拟伤口液体的碱度方面具有很高的准确性和特异性。伤口敷料类型对其检测灵敏度影响不显着。在测试人类患者废弃的伤口敷料后，该设备迅速确定了碱性和酸性伤口。最后，对不同碱度伤口的伤口尺寸缩小率的统计分析证实，伤口碱度至少对短期伤口愈合活动有很大影响。创新：该设备无需直接接触患者，即可快速评估伤口碱度，以预测即时和短期伤口愈合活动。结论：DETEC®pH可以作为伤口护理专家在常规伤口评估期间预测伤口愈合进度的预后设备。这些信息可以帮助临床环境中的决策过程，并且对慢性伤口治疗来说是个好兆头。 DETEC®pH 还可以帮助家庭保健护士或保健提供者在诊所外筛查不愈合的伤口。
Objective:While myriads of studies have suggested that a survey of wound pH environment could indicate wound healing activities, it is not clear whether wound alkalinity can be used as a prognostic indicator of nonhealing wounds. Currently available systems cannot reliably assess the pH environment across wounds, which is the objective of this study.Approach:A disposable device, DETEC®pH, was developed and characterized on its ability to map wound alkalinity by pressing a freshly recovered wound dressing against its test surface. By comparing the wound's alkalinity and size reduction rates (∼7 days) following pH measurement, we assessed the capability of wound alkalinity to prognosticate subsequent short-term wound size reduction rates.Results:The device had high accuracy and specificity in determining the alkalinity of simulated wound fluids soaked onto wound dressing. The type of wound dressing type had an insignificant effect on its detection sensitivity. Upon testing discarded wound dressings from human patients, the device quickly determined alkaline and acidic wounds. Finally, statistical analyses of wound size reduction rates in wounds with various alkalinities confirmed that wound alkalinity has a strong influence on, at least, short-term wound healing activity.Innovation:Without directly contacting the patient, this device provides a quick assessment of wound alkalinity to prognosticate immediate and short-term wound healing activities.Conclusion:DETEC®pH may serve as a prognosis device for wound care specialists during routine wound assessment to predict wound healing progress. This information can assist the decision-making process in a clinical setting and augur well for chronic wound treatment. DETEC®pH can also be used as an aid for home health care nurses or health care providers to screen nonhealing wounds outside clinics.