Attractive properties of sexual pheromones in mice:: Innate or learned?
Attractive properties of sexual pheromones in mice:: Innate or learned?
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DOI：
10.1016/s0031-9384(02)00842-9
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发表时间：
2002-09-01
影响因子：
2.9
通讯作者：
Martínez-García, F
中科院分区：
文献类型：
--
作者：
Moncho-Bogani, J;Lanuza, E;Martínez-García, F
一般认为，化学信号（性信息素）构成了许多哺乳动物性吸引的主要刺激。然而，目前还不清楚这些信息素是挥发性的还是非挥发性的，以及哪些感觉系统参与了它们的检测（犁鼻和/或嗅觉）。此外，已经证明经验影响对性信息素的行为反应和所涉及的感觉系统。为了澄清这一问题，在雌性小鼠中分析了雄性弄脏的寝具的挥发性和非挥发性组分的吸引力特性，这些雌性小鼠先前没有成年雄性衍生的化学信号的经验（化学上幼稚的雌性），使用二选一偏好测试。结果表明，一些非挥发性的男性衍生的物质发挥天然的吸引力，女性，但来自男性污染的床上用品挥发物不吸引化学幼稚的女性。因此，初级吸引性信息素包括非挥发性化合物（例如主要尿蛋白，MUP）。另一方面，雄性衍生的挥发物变得有吸引力的女性，因为反复暴露于男性污染的床上用品。这代表了一种类似巴甫洛夫的联想学习，其中先前中性的挥发物（很可能是气味剂）通过与非挥发性的、天生有吸引力的信息素相关联而获得有吸引力的特性。这些研究结果表明，不仅性，而且“化学”的经验（以前的经验与性信息素）必须考虑到解释的作用，化学物质作为杀虫剂或引物信息素。参与这些刺激的检测和神经基础的气味信息素协会的感觉系统进行了讨论。(C)2002年爱思唯尔科学公司所有的紧身衣保留。
It is generally assumed that chemical signals (sexual pheromones) constitute the primary stimulus for sexual attraction in many mammals. However, it is unclear whether these pheromones are volatile or nonvolatile and which sensory systems are involved in their detection (vomeronasal and/or olfactory). Moreover, it has been demonstrated that experience influences the behavioral response to sexual pheromones and the sensory systems implicated. In order to clarify this issue, the attractive properties of volatile and nonvolatile components of the male-soiled bedding have been analyzed in female mice that had no previous experience with adult male-derived chemical signals (chemically naive females) using two-choice preference tests. The results indicate that some nonvolatile male-derived substances exert an innate attraction to females, but volatiles derived from male-soiled bedding do not attract chemically naive females. Therefore, the primary attractive sexual pheromone includes a nonvolatile compound (e.g. major urinary proteins, MUPs). On the other hand, male-derived volatiles become attractive to females because of repeated exposure to male-soiled bedding. This represents a Pavlovian-like associative learning in which previously neutral volatiles (very likely odorants) acquire attractive properties by association with the nonvolatile, innately attractive pheromone(s). These findings indicate that not only the sexual but also the 'chemical' experience (previous experience with sexual pheromones) has to be taken into account to interpret the role of chemicals as releaser or primer pheromones. The sensory systems involved in the detection of these stimuli and the neural basis of the odor-pheromone association are discussed. (C) 2002 Elsevier Science Inc. All tights reserved.