HEPATITIS-D VIRUS AND HUMAN IMMUNODEFICIENCY VIRUS-ANTIBODIES IN PARENTERAL DRUG-ABUSERS WHO ARE HEPATITIS-B SURFACE-ANTIGEN POSITIVE
HEPATITIS-D VIRUS AND HUMAN IMMUNODEFICIENCY VIRUS-ANTIBODIES IN PARENTERAL DRUG-ABUSERS WHO ARE HEPATITIS-B SURFACE-ANTIGEN POSITIVE
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DOI：
10.1093/infdis/158.4.795
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发表时间：
1988-10-01
影响因子：
6.4
通讯作者：
KREEK, MJ
中科院分区：
文献类型：
--
作者：
NOVICK, DM;FARCI, P;KREEK, MJ
We studied unselected, hepatitis B surface antigen (HBsAg)-positive parenteral drug abusers for antibody to hepatitis D virus (anti-HD) and antibody to human immunodeficiency virus (HIV). The prevalences of anti-HD and antibody to HIV were 67% and 58%, respectively, and there was no association between positivity for these two markers. In a logistic regression model, anti-HD was associated with older age (P = .001), longer duration of drug abuse (P = .045), and the presence of liver disease (P = .002). Antibody to HIV was associated with a younger age (P = .003) and increased serum globulin levels (P < .001). In patients infected with HIV, the severity of hepatic dysfunction remained correlated with anti-HD. In anti-HD-positive patients, most indices of hepatic dysfunction were similar whether or not antibody to HIV was present, but serum aspartate aminotransferase levels were significantly higher in patients with both anti-HD and antibody to HIV (124 .+-. 16 vs. 74 .+-. 11, P < .05).
