Beta-Adrenergic Receptors, from Their Discovery and Characterization through Their Manipulation to Beneficial Clinical Application
Beta-Adrenergic Receptors, from Their Discovery and Characterization through Their Manipulation to Beneficial Clinical Application
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DOI：
10.1159/000339271
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发表时间：
2012-01-01
期刊：
影响因子：
1.9
通讯作者：
Gilbert, Edward M.
中科院分区：
文献类型：
--
作者：
Wachter, S. Blake;Gilbert, Edward M.
β-肾上腺素能受体（β-AR）是心脏功能整体调节的中心。从第一个提出的受体/递质概念到最新的临床β受体阻滞剂试验，β-AR已被证明在心脏病和心力衰竭中发挥重要作用。本研究提供了一个历史的角度来看，审查了最新的发现和信念，并讨论了目前的临床实践β-AR及其调制与相关的鸟嘌呤核苷酸调节蛋白/腺苷酸环化酶信号转导通路。版权所有（c）2012 S. Karger AG，巴塞尔
beta-Adrenergic receptors (beta-AR) are central to the overall regulation of cardiac function. From the first proposed receptor/transmitter concept to the latest clinical beta-blocker trials beta-AR have been shown to play an important role in cardiac disease and heart failure in particular. This study provides a historical perspective, reviews the latest discoveries and beliefs, and discusses the current clinical practices of beta-AR and their modulation with their associated guanine-nucleotide regulatory protein/adenylylcyclasesignal transduction pathways. Copyright (c) 2012 S. Karger AG, Basel