Corrosion behavior of nitinol in blood serum and PBS containing amino acids
Corrosion behavior of nitinol in blood serum and PBS containing amino acids
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DOI：
10.1002/jbm.b.31647
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发表时间：
2010-08-01
影响因子：
3.4
通讯作者：
Pound, Bruce G.
中科院分区：
文献类型：
--
作者：
Pound, Bruce G.
金属植入式医疗器械对局部腐蚀的敏感性通常在模拟生理溶液（例如磷酸盐缓冲盐水 (PBS)）中进行评估。对于与血液接触的植入装置，其基本前提是血液中的蛋白质和其他成分不会显着改变腐蚀敏感性。本研究检查了镍钛诺在牛血清和含有氨基酸（半胱氨酸、谷氨酰胺和色氨酸）的 PBS 中的腐蚀行为。使用循环动电位极化和电化学阻抗谱对机械抛光 (MP) 和黑色氧化 (BO) 镍钛诺丝进行测试。他们表明，MP 镍钛合金在 PBS 中的点蚀敏感性可能会受到氨基酸的存在的影响，具体取决于氨基酸的类型。然而，血清和PBS之间MP和BO镍钛诺的点蚀敏感性没有显着差异（基于t检验，p < 0.05具有统计学意义），这表明血清中蛋白质和氨基酸的组合影响不大。阻抗谱在血清中、在单独的 PBS 中以及在含有氨基酸的情况下显示出接近电容的行为，并且可以通过与钝化氧化膜相关的并联电阻电容（作为恒定相位元件）电路来拟合数据。电容表明血清蛋白被镍钛合金吸附，但在腐蚀电位下所研究的三种氨基酸的吸附即使有也很少发生。血清中有机化合物的分解和吸附之间似乎不存在相关性。 (C) 2010 Wiley periodicals, Inc. J Biomed Mater Res B 部分：Appl Biomater 94B：287-295，2010。
The susceptibility to localized corrosion of metallic, implant medical devices is typically evaluated in a simulated physiological solution, such as phosphate buffered saline (PBS). For implant devices in contact with blood, the underlying premise is that proteins and other components in blood do not significantly change the corrosion susceptibility. This study examined the corrosion behavior of nitinol in bovine serum and PBS containing amino acids (cysteine, glutamine, and tryptophan). Tests were performed on mechanically polished (MP) and black oxide (BO) nitinol wire using cyclic potentiodynamic polarization and electrochemical impedance spectroscopy. They showed that the susceptibility to pitting corrosion of MP nitinol in PBS can be influenced by the presence of amino acids, depending on the type of amino acid. However, the pitting susceptibility of MP and BO nitinol did not differ significantly (based on a t-test, with p < 0.05 being statistically significant) between serum and PBS, suggesting that the combination of proteins and amino acids in serum had little effect. The impedance spectra showed near-capacitive behavior in serum and in PBS alone and with amino acids, and the data could be fitted by a parallel resistance capacitance (as a constant phase element) circuit associated with the passive oxide film. The capacitance indicated that serum proteins were adsorbed on nitinol but that little, if any, adsorption of the three amino acids under study occurred at the corrosion potential. There did not appear to be a correlation between breakdown and the adsorption of organic compounds in serum. (C) 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 94B: 287-295, 2010.