PET AND P300 RELATIONSHIPS IN EARLY ALZHEIMERS-DISEASE
PET AND P300 RELATIONSHIPS IN EARLY ALZHEIMERS-DISEASE
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DOI：
10.1016/0197-4580(90)90015-r
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发表时间：
1990-07-01
影响因子：
4.2
通讯作者：
KUHL, D
中科院分区：
文献类型：
--
作者：
MARSH, JT;SCHUBARTH, G;KUHL, D
研究了可能患有阿尔茨海默病的患者的听觉脑事件相关电位的P300 （P3）波，以确定P300潜伏期是否将这些患者与对照组区分，以及P300潜伏期延长是否与正电子发射断层扫描测量的脑糖代谢率相关。在18名患者中，14名患者的P300潜伏期比预期年龄延长了1.5个标准差以上，但在17名对照组中没有。在这些受试者中，P300潜伏期被证明与顶叶的相对代谢率呈负相关，在较小程度上与颞叶和额叶相关区呈负相关，但与皮层下区域无关。
The P300 (P3) wave of the auditory brain event-related potential was investigated in patients with probable Alzheimer''s disease to determine whether P300 latency discriminated these patients from controls and whether prolonged P300 latency correlated with rates of brain glucose metabolism as measured by Positron Emission Tomography. P300 latency was prolonged by more than 1.5 standard deviations from age expectancy in 14 of 18 patients, but none of 17 controls. In these subjects P300 latency was shown to be inversely correlated with relative metabolic rates of parietal and, to a lesser extent, temporal and frontal association areas, but not with subcortical areas.