Antibacterial nano-structured titania coating incorporated with silver nanoparticles
Antibacterial nano-structured titania coating incorporated with silver nanoparticles
复制标题
掺入银纳米粒子的抗菌纳米结构二氧化钛涂层
DOI：
10.1016/j.biomaterials.2011.04.040
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发表时间：
2011-08-01
期刊：
影响因子：
14
通讯作者：
Chu, Paul K.
中科院分区：
文献类型：
--
作者：
Zhao, Lingzhou;Wang, Hairong;Chu, Paul K.
钛种植体在临床上应用广泛，但术后感染仍是最常见和最严重的并发症之一。具有长期抗菌能力的表面是高度期望的，以防止植入物相关的感染。在这项研究中，在钛植入物上制造了掺入银（Ag）纳米颗粒的二氧化钛纳米管（TiO 2-NTs）来实现这一目的。Ag纳米颗粒紧密地粘附在通过浸没在银硝酸盐溶液中然后通过紫外光辐射制备的TiO 2-NTs的壁上。引入到NT中的Ag的量可以通过改变诸如AgNO 3浓度和浸渍时间的处理参数来改变。负载纳米银的纳米TiO 2-NTs（NT-Ag）在最初的几天内可以杀死悬浮液中的所有细菌，并且NT-Ag防止细菌粘附的能力保持30天而没有明显下降，这通常足够长以防止植入物周围的早期和中期的术后感染，甚至可能是晚期感染。虽然NT-Ag结构显示出一定的细胞毒性，但可以通过控制Ag释放速率来降低。除了预期的TiO 2-NT的良好生物学性能外，NT-Ag材料还预期具有令人满意的骨传导性。这种可控的NT-Ag结构提供了相对长期的抗菌能力和良好的组织整合性，在骨科、牙科和其他生物医学设备中具有很好的应用前景。(C)2011爱思唯尔有限公司保留所有权利。
Titanium (Ti) implants are widely used clinically but post-operation infection remains one of the most common and serious complications. A surface boasting long-term antibacterial ability is highly desirable in order to prevent implant associated infection. In this study, titania nanotubes (TiO2-NTs) incorporated with silver (Ag) nanoparticles are fabricated on Ti implants to achieve this purpose. The Ag nanoparticles adhere tightly to the wall of the TiO2-NTs prepared by immersion in a silver nitrate solution followed by ultraviolet light radiation. The amount of Ag introduced to the NTs can be varied by changing processing parameters such as the AgNO3 concentration and immersion time. The TiO2-NTs loaded with Ag nanoparticles (NT-Ag) can kill all the planktonic bacteria in the suspension during the first several days, and the ability of the NT-Ag to prevent bacterial adhesion is maintained without obvious decline for 30 days, which are normally long enough to prevent post-operation infection in the early and intermediate stages and perhaps even late infection around the implant. Although the NT-Ag structure shows some cytotoxicity, it can be reduced by controlling the Ag release rate. The NT-Ag materials are also expected to possess satisfactory osteoconductivity in addition to the good biological performance expected of TiO2-NTs. This controllable NT-Ag structure which provides relatively long-term antibacterial ability and good tissue integration has promising applications in orthopedics, dentistry, and other biomedical devices. (C) 2011 Elsevier Ltd. All rights reserved.