Synthesis and mass spectrometry of benzoxazoline, dimethyloxazoline and 4-phenyloxazoline derivatives of polyunsaturated fatty acids
Synthesis and mass spectrometry of benzoxazoline, dimethyloxazoline and 4-phenyloxazoline derivatives of polyunsaturated fatty acids
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DOI：
10.1002/rcm.3071
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发表时间：
2007-01-01
影响因子：
2
通讯作者：
Evans, Rhobert W.
中科院分区：
文献类型：
--
作者：
Kangani, Cyrous O.;Kelley, David E.;Evans, Rhobert W.
环氮部分已被证明是非常有价值的多不饱和脂肪酸中的双键的质谱定位。然而，它们的合成传统上需要长的反应时间和/或高温。最近，我们介绍了一种一锅法，高产率，温和和有效的合成各种脂肪酸酰胺衍生物的方法。我们现在已经扩展了这一程序，包括合成苯并恶唑啉，二甲基恶唑啉和4-苯基恶唑啉类似物的一系列脂肪酸含有18至22个碳原子和0至6个双键。描述了这些饱和和不饱和脂肪酸的三种衍生物的质谱性质的比较。版权所有（C）2007约翰威利父子有限公司
Cyclic nitrogen moieties have proved to be of great value for the mass spectrometric location of double bonds in polyunsaturated fatty acids. However, their synthesis has traditionally required long reaction times and/or high temperatures. Recently, we introduced a one-pot, high-yield, mild and efficient method for the synthesis of various fatty acid amide derivatives. We have now extended this procedure to include the synthesis of benzoxazoline, dimethyloxazoline and 4-phenyloxazoline analogs of a series of fatty acids containing 18 to 22 carbon atoms and 0 to 6 double bonds. A comparison of the mass spectral properties of the three derivatives of these saturated and unsaturated fatty acids is described. Copyright (C) 2007 John Wiley & Sons, Ltd.