A new interpretation of thalamocortical circuitry
A new interpretation of thalamocortical circuitry
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DOI：
10.1098/rstb.2002.1164
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发表时间：
2002-12-29
期刊：
影响因子：
--
通讯作者：
Cox, K
中科院分区：
文献类型：
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作者：
Adams, P;Cox, K
几乎所有指定丘脑皮层和新皮层线路所需的信息都来自由环境引起的模式电活动。连接的准确性必须受到由神经活动触发的级联事件的解剖学特异性的限制，并最终导致突触形成。我们提出了一个简单的学习模型在可塑性错误的存在。实现学习特异性的一种方法是建立更好的突触。我们讨论了另一种基于电路的方法，该方法只允许支持高度选择性关联的连接具有可塑性。这个回路类似于丘脑皮层回路的一些更令人困惑的方面。
Almost all the information that is needed to specify thalamocortical and neocortical wiring derives from patterned electrical activity induced by the environment. Wiring accuracy must be limited by the anatomical specificity of the cascade of events triggered by neural activity and culminating in synaptogenesis. We present a simple model of learning in the presence of plasticity errors. One way to achieve learning specificity is to build better synapses. We discuss an alternative, circuit-based, approach that only allows plasticity at connections that support highly selective correlations. This circuit resembles some of the more puzzling aspects of thalamocorticothalamic circuitry.